Record in detail


General Info

  • lamp_id:L01A003084
  • Name:VARF_VIOAR
  • FullName:Varv peptide F
  • Source:Viola arvensis
  • Mass:2983.4 Da
  • Sequence Length:29 aa
  • Isoelectric Point:5.93
  • Activity:Antimicrobial, ,Anticancer
  • Sequence
        GVPICGETCTLGTCYTAGCSCSWPVCTRN
  • Function:Probably participates in a plant defense mechanism. Has cytotoxic activity against a variety of drug-resistant and drug-sensitive human tumor cell lines.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003084    From 1 To 29 E-value: 0.00000000002 Score: 59.7
        GVPICGETCTLGTCYTAGCSCSWPVCTRN
  • 2. L06AT00219    From 1 To 29 E-value: 0.0000000004 Score: 55.1
        GLPVCGETCTLGKCYTAGCSCSWPVCYRN
  • 3. L02A001054    From 1 To 29 E-value: 0.000000001 Score: 53.9
        GLPVCGETCTLGTCYTQGCTCSWPICKRN
  • 4. L02A001119    From 1 To 29 E-value: 0.000000002 Score: 52.8
        GLPVCGETCAFGSCYTPGCSCSWPVCTRN
  • 5. L12A00829|    From 1 To 25 E-value: 0.000000004 Score: 52
        CGETCTLGTCYTAGCSCSWPVCTRN

Structure

  •   Domains
  •   1  Name:Cyclotide    Interpro Link:IPR005535
  •   2  Name:Cyclotide_moebius_CS    Interpro Link:IPR012324
  •   3  Name:Cyclotide_subgr    Interpro Link:IPR017307
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  human tumor cell lines  IC50:  22.08 μg/ml  (7.40095 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Claeson P.,Bohlin L.,Johansson S.,Luijendijk T.,Goeransson U.,
  •   Title:Seven novel macrocyclic polypeptides from Viola arvensis.
  •   Journal:J. Nat. Prod., 1999, 62, 283-286  [MEDLINE:99177275]
  •   [2]  Gullbo J.,Claeson P.,Johansson S.,Goransson U.,Lindholm P.,
  •   Title:Cyclotides: a novel type of cytotoxic agents.
  •   Journal:Mol. Cancer Ther., 2002, 1, 365-369  [PubMed:12477048]

Comments

  •   Comments

    •     No comments found on LAMP database



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