Record in detail


General Info

  • lamp_id:L01A003091
  • Name:AMP1_MACIN
  • FullName:Antimicrobial peptide 1
  • Source:Macadamia integrifolia
  • Mass:8138 Da
  • Sequence Length:76 aa
  • Isoelectric Point:8.84
  • Activity:Antibacterial, Antifungal
  • Sequence
        SAFTVWSGPGCNNRAERYSKCGCSAIHQKGGYDFSYTGQTAALYNQAGCSGVAHTRFGSSARACNPFGWKSIFIQC
  • Function:Antimicrobial peptide which inhibits the growth of a variety of fungi, oomycetes, Gram-positive bacterial phytopatogenes and S.cerevisiae in vitro. No activity against E.coli.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003091    From 1 To 76 E-value: 8.00001e-41 Score: 157
        SAFTVWSGPGCNNRAERYSKCGCSAIHQKGGYDFSYTGQTAALYNQAGCSGVAHTRFGSSARACNPFGWKSIFIQC
  • 2. L13A028418    From 1 To 50 E-value: 5e-25 Score: 104
        SAFTVWSGPGCNNRAERYSKCGCSAIHQKGGYDFSYTGQTAALYNQAGCS
  • 3. L01A002890    From 1 To 79 E-value: 4e-23 Score: 98.6
        SYFTAWAGPGCNNHAARYSKCGCSNIGNNVHGGYEFMYQGQTAAAYNTDNCKGVAQTRFSSSVNQACSSFGWKSFFIQC
  • 4. L01A003271    From 1 To 79 E-value: 2e-22 Score: 95.9
        SYFSAWAGPGCNNHNARYSKCGCSNIGHNVHGGYEFVYQGQTAAAYNTDNCKGVAQTRFSSSVNQACSNFGWKSVFIQC

Structure

  •   Domains
  •   1  Name:Antimic/Inh_G_crystallin-like    Interpro Link:IPR015791
  •   2  Name:Antimicrobial_MiAMP1    Interpro Link:IPR015201
  •   3  Name:G_crystallin-rel    Interpro Link:IPR011024
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  Alternaria helianthi  MIC:  2 μg/ml  (0.245761 μM)  
  •   2  Target:  Botrytis cinerea  MIC:  5 μg/ml  (0.614402 μM)  
  •   3  Target:  Ceratocystis parodoxa  MIC:  20 μg/ml  (2.45761 μM)  
  •   4  Target:  Colletotrichum gloeosporioides  MIC:  2 μg/ml  (0.245761 μM)  
  •   5  Target:  Fusurium oxysporum  MIC:  2 μg/ml  (0.245761 μM)  
  •   6  Target:  Leptosphaeria maculans  MIC:  5 μg/ml  (0.614402 μM)  
  •   7  Target:  Phytophthoru cryptogea  MIC:  5 μg/ml  (0.614402 μM)  
  •   8  Target:  Pythium graminicola  MIC:  5 μg/ml  (0.614402 μM)  
  •   9  Target:  Sclerotinia sclerotiorum spores  MIC:  5 μg/ml  (0.614402 μM)  
  •   10  Target:  Sclerotinia sclerotiorum mycelia  MIC:  50 μg/ml  (6.14402 μM)  
  •   11  Target:  Verticilium dahliae  MIC:  2 μg/ml  (0.245761 μM)  
  •   12  Target:  Clavibacter michiganensis  MIC:  10 μg/ml  (1.2288 μM)  
  •   13  Target:  Saccharomyces cerevisiae  MIC:  2 μg/ml  (0.245761 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Manners J.M.,Harrison S.J.,Goulter K.C.,Green J.L.,Marcus J.P.,
  •   Title:Purification, characterisation and cDNA cloning of an antimicrobial peptide from Macadamia integrifolia.
  •   Journal:Eur. J. Biochem., 1997, 244, 743-749  [MEDLINE:97261828]
  •   [2]  Green J.L.,Harrison S.J.,Marcus J.P.,Nielsen K.J.,McManus A.M.,
  •   Title:MiAMP1, a novel protein from Macadamia integrifolia adopts a Greek key beta-barrel fold unique amongst plant antimicrobial proteins.
  •   Journal:J. Mol. Biol., 1999, 293, 629-638  [MEDLINE:20013073]

Comments

  •   Comments

    •     No comments found on LAMP database



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