Record in detail

lamp_id:L01A003111
Name:OSTR1_STRCA
FullName:Ostricacin-1
Source:Struthio camelus
Mass:4017.8 Da
Sequence Length:36 aa
Isoelectric Point:8.64
Activity:Antibacterial
Sequence
LFCRKGTCHFGGCPAHLVKVGSCFGFRACCKWPWDV
Function:Has antibacterial activity against the Gram-positive bacteria S.aureus 1056 MRSA (MIC=1.25 ug/ml) and S.aureus NCTC 4163 (MIC=6.7 ug/ml), and the Gram-negative bacteria E.coli O157:H7 (MIC=0.96 ug/ml) and E.coli 0111 (MIC=6.7 ug/ml). Does not have antifungal activity against the yeast C.albicans 3153A.

Top similar AMPs on LAMP
1. L01A003111 From 1 To 36 E-value: 2e-16 Score: 75.9
LFCRKGTCHFGGCPAHLVKVGSCFGFRACCKWPWDV
2. L03A000255 From 29 To 64 E-value: 0.00000000000002 Score: 69.7
LFCKRGTCHFGRCPSHLIKVGSCFGFRSCCKWPWDA
3. L12A09039| From 29 To 64 E-value: 0.00000000000003 Score: 68.9
LFCKRGSCHFGRCPSHLIKVGSCFGFRSCCKWPWDA
4. L05ADEF300 From 29 To 64 E-value: 0.00000000000005 Score: 68.2
LFCKGGSCHFGGCPSHLIKVGSCFGFRSCCKWPWNA
5. L02A000267 From 1 To 36 E-value: 0.00000000000005 Score: 68.2
LFCKRGTCHFGRCPSHLIKVGSCFGFRSCCKWPWDA

Antibacterial Activities
1 Target: S.aureus 1056 MRSA MIC: 1.25 μg/ml (0.311116 μM)
2 Target: S.aureus NCTC 4163 MIC: 6.7 μg/ml (1.66758 μM)
3 Target: E.coli O157:H7 MIC: 0.96 μg/ml (0.238937 μM)
4 Target: E.coli 0111 MIC: 6.7 μg/ml (1.66758 μM)

Reference
[1] Ahrens K.,Choudhury S.D.,Yu P.-L.,
Title:Purification and characterization of the antimicrobial peptide, ostricacin.
Journal:Biotechnol. Lett., 2001, 23, 207-210 [:]
[2] Yu P.-L.,Sugiarto H.,
Title:Identification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins.
Journal:Int. J. Antimicrob. Agents, 2006, 27, 229-235 [PubMed:16459058]