Record in detail


General Info

  • lamp_id:L01A003124
  • Name:HEPC_HUMAN
  • FullName:Hepcidin
  • Source:Homo sapiens
  • Mass:2797.4 Da
  • Sequence Length:25 aa
  • Isoelectric Point:7.98
  • Activity:Antibacterial, Antifungal
  • Sequence
        DTHFPICIFCCGCCHRSKCGMCCKT
  • Function:Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A06333|    From 60 To 84 E-value: 0.0000000001 Score: 56.6
        DTHFPICIFCCGCCHRSKCGMCCKT
  • 2. L12A06331|    From 61 To 85 E-value: 0.0000000001 Score: 56.6
        DTHFPICIFCCGCCHRSKCGMCCKT
  • 3. L01A001835    From 60 To 84 E-value: 0.0000000002 Score: 56.6
        DTHFPICIFCCGCCHRSKCGMCCKT
  • 4. L12A08786|    From 57 To 81 E-value: 0.0000000004 Score: 55.5
        DTHFPICMFCCGCCHRSKCGMCCKT
  • 5. L12A06334|    From 60 To 84 E-value: 0.0000000005 Score: 54.7
        DTHFPICIFCCGCCHRSKCGMCCRT

Structure

  •   Domains
  •   1  Name:Hepcidin    Interpro Link:IPR010500
  •   Structures

Activity

  •   Antibacterial Activities
  •   1  Target:  E.�coli ML35p S. epidermidis S. aureus C. albica  MIC:  50 μg/ml  (17.8737 μM)  
  •   2  Target:  B.subtilis  MIC:  40 μg/ml  (14.299 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Forssmann W.-G.,Schulz A.,Maegert H.-J.,Neitz S.,Krause A.,
  •   Title:LEAP-1, a novel highly disulfide-bonded human peptide exhibits antimicrobial activity.
  •   Journal:FEBS Lett., 2000, 480, 147-150  [MEDLINE:20487130]
  •   [2]  Ganz T.,Waring A.J.,Valore E.V.,Park C.H.,
  •   Title:Hepcidin: a urinary antimicrobial peptide synthesized in the liver.
  •   Journal:J. Biol. Chem., 2001, 276, 7806-7810  [PubMed:11113131]
  •   [3]  Adermann K.,Forssmann W.-G.,Schulz A.,Kluever E.,
  •   Title:Chemical synthesis of beta-defensins and LEAP-1/hepcidin.
  •   Journal:J. Pept. Res., 2002, 59, 241-248  [MEDLINE:22007551]
  •   [4]  Vogel H.J.,Ganz T.,Fulton D.B.,Hunter H.N.,
  •   Title:The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis.
  •   Journal:J. Biol. Chem., 2002, 277, 37597-37603  [PubMed:12138110]
  •   [5]  Viprakasit V.,Capron D.,Bomford A.,Cadet E.,Merryweather-Clarke A.T.,
  •   Title:Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis.
  •   Journal:Hum. Mol. Genet., 2003, 12, 2241-2247  [PubMed:12915468]
  •   [6]  Gerardi G.,Zanella I.,Ruggeri G.,Belloli S.,Biasiotto G.,
  •   Title:Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload.
  •   Journal:Clin. Chem., 2003, 49, 1981-1988  [PubMed:14633868]
  •   [7]  Baldwin D.T.,Baker K.,Abaya E.,Gurney A.L.,Clark H.F.,
  •   Title:The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
  •   Journal:Genome Res., 2003, 13, 2265-2270  [MEDLINE:22887296]
  •   [8]  Radomski C.,MacFarlane J.,Gow P.,Allen K.J.,Delatycki M.B.,
  •   Title:A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis.
  •   Journal:Clin. Genet., 2004, 65, 378-383  [PubMed:15099344]
  •   [9]  Mura C.,Quere I.,Scotet V.,Le Gac G.,Jacolot S.,
  •   Title:HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype.
  •   Journal:Blood, 2004, 103, 2835-2840  [PubMed:14670915]
  •   [10]  Cox T.M.,Caruso R.,Porporato P.,Daraio F.,Roetto A.,
  •   Title:Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R).
  •   Journal:Blood, 2004, 103, 2407-2409  [PubMed:14630809]
  •   [11]  Schmutz J.,Terry A.,Olsen A.S.,Gordon L.A.,Grimwood J.,
  •   Title:The DNA sequence and biology of human chromosome 19.
  •   Journal:Nature, 2004, 428, 529-535  [PubMed:15057824]
  •   [12]  
  •   Title:The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  •   Journal:Genome Res., 2004, 14, 2121-2127  [PubMed:15489334]
  •   [13]  Syed R.,Arvedson T.,Haniu M.,Poppe L.,Jordan J.B.,
  •   Title:Hepcidin revisited, disulfide connectivity, dynamics, and structure.
  •   Journal:J. Biol. Chem., 2009, 284, 24155-24167  [PubMed:19553669]

Comments

  •   Comments

    •     No comments found on LAMP database



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