Record in detail
General Info
- lamp_id:L01A003148
- Name:TXFK2_PSACA
- FullName:U2-theraphotoxin-Pc1a
- Source:Psalmopoeus cambridgei
- Mass:2956.5 Da
- Sequence Length:28 aa
- Isoelectric Point:8.91
- Activity:Antiparasitic
- Sequence
RCLPAGKTCVRGPMRVPCCGSCSQNKCT - Function:Possess strong antiplasmodial activity against the intra-erythrocyte stage of P.falciparum in vitro. IC(50) for inhibiting P.falciparum growth is 1.15 uM. Specifically interacts with infected erythrocytes. Does not lyse erythrocytes, is not cytotoxic to nucleated mammalian cells, and does not inhibit neuromuscular function. Has neither antibacterial nor antifungal activity.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ985
- 2 Database:DBAASP 4466
- 3 Database:dbAMP dbAMP_10360
- 4 Database:DRAMP DRAMP00298
- 5 Database:SATPdb satpdb16828
- 6 Database:Uniprot P0C202
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A003148 From 1 To 28 E-value: 0.00000000007 Score: 57.8
RCLPAGKTCVRGPMRVPCCGSCSQNKCT - 2. L12A00832| From 2 To 23 E-value: 2.5 Score: 22.7
GETCVGGTCNTPGC-TCSKNKCT
Structure
- Domains
No domains found on LAMP database
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Delarbre C.,Deregnaucourt C.,Guillaume C.,Parent R.,Choi S.-J.,
- Title:Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei.
- Journal:FEBS Lett., 2004, 572, 109-117 [PubMed:15304333]
Comments
- Comments
No comments found on LAMP database