Record in detail


General Info

  • lamp_id:L01A003152
  • Name:3CP2_STRSQ
  • FullName:Tricyclic peptide MS-271
  • Source:Streptomyces sp.
  • Mass:2184.5 Da
  • Sequence Length:21 aa
  • Isoelectric Point:5.74
  • Activity:Antibacterial
  • Sequence
        CLGVGSCNNFAGCGYAIVCFW
  • Function:Inhibits chicken myosin light chain kinase with an IC(50) of 8 M. Does not inhibit bovine cAMP-dependent protein kinase or rat protein kinase C. Antibacterial activity against the Gram-positive bacteria B.subtilis, E.faecium and S.aureus. No antibacterial activity against the Gram-negative bacteria E.coli, K.pneumoniae, P.aeruginosa, P.vulgaris, S.sonnei and S.typhosa. No antifungal activity against C.albicans.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003152    From 1 To 21 E-value: 0.0000006 Score: 44.3
        CLGVGSCNNFAGCGYAIVCFW
  • 2. L02A001138    From 1 To 21 E-value: 0.000001 Score: 43.5
        CLGVGSCNDFAGCGYAIVCFW
  • 3. L13A024979    From 1 To 21 E-value: 0.000002 Score: 43.1
        CLGIGSCNDFAGCGYAIVCFW
  • 4. L02A001137    From 1 To 21 E-value: 0.000002 Score: 42.7
        CLGVGSCNDFAGCGYAVVCFW
  • 5. L01A002711    From 1 To 21 E-value: 0.000002 Score: 42.4
        CLGIGSCNDFAGCGYAVVCFW

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Ando K.,Ochiai K.,Nakanishi S.,Toki S.,Yano K.,
  •   Title:MS-271, a novel inhibitor of calmodulin-activated myosin light chain kinase from Streptomyces sp. -- I. Isolation, structural determination and biological properties of MS-271.
  •   Journal:Bioorg. Med. Chem., 1996, 4, 115-120  [PubMed:8689231]
  •   [2]  Yoshida M.,Matsuda Y.,Yamasaki M.,Katahira R.,
  •   Title:MS-271, a novel inhibitor of calmodulin-activated myosin light chain kinase from Streptomyces sp. -- II. Solution structure of MS-271: characteristic features of the "lasso" structure.
  •   Journal:Bioorg. Med. Chem., 1996, 4, 121-129  [PubMed:8689232]

Comments

  •   Comments

    •     No comments found on LAMP database



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