Record in detail


General Info

  • lamp_id:L01A003156
  • Name:HEPC2_DANRE
  • FullName:Hepcidin-2
  • Source:Danio rerio
  • Mass:2891.5 Da
  • Sequence Length:25 aa
  • Isoelectric Point:8.6
  • Activity:Antimicrobial
  • Sequence
        QSHLSLCRFCCKCCRNKGCGYCCKF
  • Function:Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003156    From 1 To 25 E-value: 0.00000001 Score: 50.4
        QSHLSLCRFCCKCCRNKGCGYCCKF
  • 2. L12A01558|    From 18 To 42 E-value: 0.00000003 Score: 48.9
        QSHLSMCRYCCKCCRNKGCGFCCKF
  • 3. L12A07592|    From 61 To 85 E-value: 0.00000003 Score: 48.9
        QSHLSLCRWCCKCCHNKGCGFCCKF
  • 4. L12A07597|    From 64 To 88 E-value: 0.0000001 Score: 47
        QSHLSLCRWCCNCCHNKGCGFCCKF
  • 5. L12A07596|    From 64 To 88 E-value: 0.0000001 Score: 47
        QSHLSLCRWCCNCCHNKGCGFCCKF

Structure

  •   Domains
  •   1  Name:Hepcidin    Interpro Link:IPR010500
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Burns J.C.,Lauth X.,Shimizu C.,Shike H.,
  •   Title:Organization and expression analysis of the zebrafish hepcidin gene, an antimicrobial peptide gene conserved among vertebrates.
  •   Journal:Dev. Comp. Immunol., 2004, 28, 747-754  [PubMed:15043943]

Comments

  •   Comments

    •     No comments found on LAMP database



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