Record in detail


General Info

  • lamp_id:L01A003157
  • Name:HEPC_RAT
  • FullName:Hepcidin
  • Source:Rattus norvegicus
  • Mass:2720.2 Da
  • Sequence Length:25 aa
  • Isoelectric Point:7.6
  • Activity:Antimicrobial
  • Sequence
        DTNFPICLFCCKCCKNSSCGLCCIT
  • Function:Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000100    From 60 To 84 E-value: 0.0000000008 Score: 54.3
        DTNFPICLFCCKCCKNSSCGLCCIT
  • 2. L01A003157    From 1 To 25 E-value: 0.00000002 Score: 49.7
        DTNFPICLFCCKCCKNSSCGLCCIT
  • 3. L03A000101    From 59 To 83 E-value: 0.0000002 Score: 46.2
        DTNFPICIFCCKCCNNSQCGICCKT
  • 4. L01A002853    From 1 To 25 E-value: 0.000002 Score: 42.7
        DTNFPICIFCCKCCNNSQCGICCKT
  • 5. L01A002633    From 35 To 59 E-value: 0.000002 Score: 42.7
        DTHFPICIFCCGCCKTPKCGLCCIT

Structure

  •   Domains
  •   1  Name:Hepcidin    Interpro Link:IPR010500
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Turlin B.,Leroyer P.,Courselaud B.,Ilyin G.,Pigeon C.,
  •   Title:A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload.
  •   Journal:J. Biol. Chem., 2001, 276, 7811-7819  [MEDLINE:21269329]

Comments

  •   Comments

    •     No comments found on LAMP database



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