Record in detail


General Info

  • lamp_id:L01A003158
  • Name:HEPC_ONCMY
  • FullName:Hepcidin
  • Source:Oncorhynchus mykiss
  • Mass:2764.2 Da
  • Sequence Length:25 aa
  • Isoelectric Point:8.3
  • Activity:Antibacterial
  • Sequence
        XSHLSLCRWCCNCCHNKGXGFCCKF
  • Function:Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000074    From 38 To 61 E-value: 0.000000009 Score: 50.4
        SHLSLCRWCCNCCHNKGXGFCCKF
  • 2. L12A07597|    From 65 To 88 E-value: 0.00000001 Score: 50.4
        SHLSLCRWCCNCCHNKGCGFCCKF
  • 3. L12A07596|    From 65 To 88 E-value: 0.00000001 Score: 50.4
        SHLSLCRWCCNCCHNKGCGFCCKF
  • 4. L12A07592|    From 62 To 85 E-value: 0.00000003 Score: 48.9
        SHLSLCRWCCKCCHNKGCGFCCKF
  • 5. L01A003158    From 2 To 25 E-value: 0.00000007 Score: 47.8
        SHLSLCRWCCNCCHNKGXGFCCKF

Structure

  •   Domains
  •   1  Name:Hepcidin    Interpro Link:IPR010500
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Yano T.,Nakao M.,Fujiki K.,Gerwick L.,Bayne C.J.,
  •   Title:Immune-relevant (including acute phase) genes identified in the livers of rainbow trout, Oncorhynchus mykiss, by means of suppression subtractive hybridization.
  •   Journal:Dev. Comp. Immunol., 2001, 25, 205-217  [PubMed:11164886]

Comments

  •   Comments

    •     No comments found on LAMP database



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