Record in detail
General Info
- lamp_id:L01A003163
- Name:GRAH2_RANGR
- FullName:Grahamin-2
- Source:Rana grahami
- Mass:1968.4 Da
- Sequence Length:21 aa
- Isoelectric Point:8.24
- Activity:Antibacterial, Antifungal
- Sequence
GLLSGILGAGKHIVCGLSGLC - Function:Potent microbicidal activity, active against the Gram positive bacterium S.aureus and against the Gram-negative bacteria E.coli and B.dysenteriae. Has antifungal activity against C.albicans. Lacks hemolytic activity against rabbit erythrocytes.
Cross-Linking
- Cross-linking
- 1 Database:APD 579
- 2 Database:APD 1313
- 3 Database:CAMP CAMPSQ995
- 4 Database:DBAASP 1524
- 5 Database:dbAMP dbAMP_03598
- 6 Database:DRAMP DRAMP01417
- 7 Database:SATPdb satpdb24837
- 8 Database:Uniprot P85070
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L12A07186| From 46 To 66 E-value: 0.000002 Score: 42.7
GLLSGILGAGKHIVCGLSGLC - 2. L01A003163 From 1 To 21 E-value: 0.00001 Score: 39.7
GLLSGILGAGKHIVCGLSGLC - 3. L12A07348| From 47 To 67 E-value: 0.00002 Score: 39.7
GLLSGILGAGKNIVCGLSGLC - 4. L13A015420 From 1 To 21 E-value: 0.00002 Score: 39.3
GLLSGVLGAGKHIVCGLSGLC - 5. L13A021484 From 1 To 21 E-value: 0.00002 Score: 39.3
GLLSGILGAGKHVVCGLSGLC
Activity
- Antibacterial Activities
- 1 Target: E. coli MIC: 98.42 μg/ml (50 μM)
- 2 Target: S. aureus MIC: 196.84 μg/ml (100 μM)
- 3 Target: C. albicans MIC: 196.84 μg/ml (100 μM)
- 4 Target: E. coli MIC: 5.01942 μg/ml (2.55 μM)
- 5 Target: S. aureus MIC: 2.49987 μg/ml (1.27 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Liang J.,Yang H.,Han Y.,Li J.,Xu X.,
- Title:Two antimicrobial peptides from skin secretions of Rana grahami.
- Journal:Toxicon, 2006, 47, 459-464 [PubMed:16487561]
Comments
- Comments
No comments found on LAMP database