Record in detail


General Info

  • lamp_id:L01A003163
  • Name:GRAH2_RANGR
  • FullName:Grahamin-2
  • Source:Rana grahami
  • Mass:1968.4 Da
  • Sequence Length:21 aa
  • Isoelectric Point:8.24
  • Activity:Antibacterial, Antifungal
  • Sequence
        GLLSGILGAGKHIVCGLSGLC
  • Function:Potent microbicidal activity, active against the Gram positive bacterium S.aureus and against the Gram-negative bacteria E.coli and B.dysenteriae. Has antifungal activity against C.albicans. Lacks hemolytic activity against rabbit erythrocytes.

Cross-Linking

  •   Cross-linking
  •   1  Database:APD  579
  •   2  Database:APD  1313
  •   3  Database:CAMP  CAMPSQ995
  •   4  Database:DBAASP  1524
  •   5  Database:dbAMP  dbAMP_03598
  •   6  Database:DRAMP  DRAMP01417
  •   7  Database:SATPdb  satpdb24837
  •   8  Database:Uniprot  P85070

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A07186|    From 46 To 66 E-value: 0.000002 Score: 42.7
        GLLSGILGAGKHIVCGLSGLC
  • 2. L01A003163    From 1 To 21 E-value: 0.00001 Score: 39.7
        GLLSGILGAGKHIVCGLSGLC
  • 3. L12A07348|    From 47 To 67 E-value: 0.00002 Score: 39.7
        GLLSGILGAGKNIVCGLSGLC
  • 4. L13A015420    From 1 To 21 E-value: 0.00002 Score: 39.3
        GLLSGVLGAGKHIVCGLSGLC
  • 5. L13A021484    From 1 To 21 E-value: 0.00002 Score: 39.3
        GLLSGILGAGKHVVCGLSGLC

Structure

  •   Domains
  •   1  Name:Brevinin    Interpro Link:IPR004275
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  98.42 μg/ml  (50 μM)  
  •   2  Target:  S. aureus  MIC:  196.84 μg/ml  (100 μM)  
  •   3  Target:  C. albicans  MIC:  196.84 μg/ml  (100 μM)  
  •   4  Target:  E. coli  MIC:  5.01942 μg/ml  (2.55 μM)  
  •   5  Target:  S. aureus  MIC:  2.49987 μg/ml  (1.27 μM)  

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Liang J.,Yang H.,Han Y.,Li J.,Xu X.,
  •   Title:Two antimicrobial peptides from skin secretions of Rana grahami.
  •   Journal:Toxicon, 2006, 47, 459-464  [PubMed:16487561]

Comments

  •   Comments

  •     No comments found on LAMP database



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