Record in detail

lamp_id:L01A003273
Name:CLY_CONMS
FullName:Conolysin-Mt1
Source:Conus mustelinus
Mass:2750.3 Da
Sequence Length:23 aa
Isoelectric Point:10.9
Activity:Antibacterial
Sequence
FHPSLWVLIPQYIQLIRKILKSG
Function:This cytolytic peptide has ability to disrupt the integrity of cell membranes from both prokaryotes and eukaryotes. It permeabilizes both negatively charged prokaryotic (PE:PG) and zwitterionic eukaryotic (PC:cholesterol) model membranes. It has potent hemolytic activity on human erythrocytes and exhibits low antimicrobial activity against the Gram-negative bacterium E.coli (MIC>50 uM) and the Gram-positive bacterium S.aureus (MIC=25-50 uM). Intracranial injection causes mice to shuffle backward until the encounter an obstacle, at which time the mouse jump into the air. The backward shuffle is reminiscent to the signature dance "moonwalk" that gained widespread popularity after being performed by Michael Jackson.

Top similar AMPs on LAMP
1. L01A003273 From 1 To 23 E-value: 0.00000004 Score: 48.5
FHPSLWVLIPQYIQLIRKILKSG
2. L13A020788 From 1 To 22 E-value: 0.0000002 Score: 45.8
FHPSLWVLIPQYIQLIRKILKS