Record in detail

lamp_id:L01A003280
Name:DMS5_PHYAZ
FullName:Dermaseptin-H5
Source:Phyllomedusa azurea
Mass:2454.9 Da
Sequence Length:25 aa
Isoelectric Point:10.51
Activity:Antibacterial
Sequence
GLWSTIKNVGKEAAIAAGKAVLGSL
Function:Has antibacterial activity against the Gram-negative bacteria E.coli ATCC 11775 (MIC=0.5 uM), and the Gram-positive bacteria S.aureus ATCC 12600 (MIC=0.5 uM) and M.luteus ATCC 49732 (MIC=2.0 uM). Does not inhibit the growth of the fungus C.albicans. Probably acts by disturbing membrane functions with its amphipathic structure.

Top similar AMPs on LAMP
1. L12A05358| From 41 To 65 E-value: 0.00000001 Score: 50.4
GLWSTIKNVGKEAAIAAGKAVLGSL
2. L02A001352 From 1 To 25 E-value: 0.00000004 Score: 48.5
GLWSTIKNVGKEAAIAAGKAVLGSL
3. L01A003280 From 1 To 25 E-value: 0.00000005 Score: 48.1
GLWSTIKNVGKEAAIAAGKAVLGSL
4. L13A024422 From 1 To 24 E-value: 0.0000002 Score: 46.6
GLWSTIKNVGKEAAIAAGKAVLGS
5. L03A000083 From 46 To 73 E-value: 0.006 Score: 31.2
GMWSTIRNVGKSAAKAANLPAKAALGAI

Antibacterial Activities
1 Target: E. coli ATCC 11775 MIC: 1.23 μg/ml (0.501039 μM)
2 Target: S.aureus ATCC 12600 MIC: 1.23 μg/ml (0.501039 μM)
3 Target: M. luteus ATCC 49732 MIC: 4.91 μg/ml (2.00008 μM)
4 Target: E. coli MIC: 1.22745 μg/ml (0.5 μM)
5 Target: S. aureus MIC: 1.22745 μg/ml (0.5 μM)

Reference
[1] McClean S.,Shaw C.,Orr D.F.,Bjourson A.J.,Thompson A.H.,
Title:A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.
Journal:Peptides, 2007, 28, 1331-1343 [PubMed:17553595]