Record in detail


General Info

  • lamp_id:L01A003298
  • Name:M3H5_BOMMX
  • FullName:Maximins 3/H5
  • Source:Bombina maxima
  • Mass:2022.4 Da
  • Sequence Length:20 aa
  • Isoelectric Point:3.34
  • Activity:Antibacterial
  • Sequence
        ILGPVLGLVSDTLDDVLGIL
  • Function:Maximin-3 shows antibacterial activity against both Gram-positive and Gram-negative bacteria. It shows also antimicrobial activity against the fungus C.albicans, but not against A.flavus nor P.uticale. It has little hemolytic activity. It possess a significant cytotoxicity against tumor cell lines. It possess a significant anti-HIV activity. It shows high spermicidal activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003298    From 1 To 20 E-value: 0.0001 Score: 36.6
        ILGPVLGLVSDTLDDVLGIL
  • 2. L13A028692    From 1 To 20 E-value: 0.0002 Score: 35.4
        ILGPVLGLVSNTLDDVLGIL
  • 3. L13A028056    From 1 To 19 E-value: 0.0003 Score: 35.4
        ILGPVLGLVSDTLDDVLGI
  • 4. L13A017238    From 1 To 20 E-value: 0.0007 Score: 34.3
        ILGPVLGLVSGTLDDVLGIL
  • 5. L13A011196    From 1 To 20 E-value: 0.0008 Score: 33.9
        ILGPVLGLVSNALDDVLGIL

Structure

  •   Domains
  •   1  Name:Bombinin    Interpro Link:IPR007962
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  202.24 μg/ml  (100 μM)  
  •   2  Target:  S. aureus  MIC:  161.792 μg/ml  (80 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Zhang Y.,Lee W.-H.,Liu H.,Lai R.,
  •   Title:An anionic antimicrobial peptide from toad Bombina maxima.
  •   Journal:Biochem. Biophys. Res. Commun., 2002, 295, 796-799  [MEDLINE:22122290]
  •   [2]  Liu H.,Liu G.-J.,Shen J.-H.,Zheng Y.-T.,Lai R.,
  •   Title:Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
  •   Journal:Peptides, 2002, 23, 427-435  [MEDLINE:21826911]
  •   [3]  Zhang Y.,Li S.,Lai R.,Li Y.,Lee W.-H.,
  •   Title:Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification.
  •   Journal:Eur. J. Immunol., 2005, 35, 1220-1229  [PubMed:15770703]

Comments

  •   Comments

    •     No comments found on LAMP database



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