Record in detail


General Info

  • lamp_id:L01A003300
  • Name:MAST_ANTFM
  • FullName:Eumenine mastoparan-AF
  • Source:Anterhynchium flavomarginatum micado
  • Mass:1523.9 Da
  • Sequence Length:14 aa
  • Isoelectric Point:11.1
  • Activity:Antibacterial
  • Sequence
        INLLKIAKGIIKSL
  • Function:Mast cell degranulating peptide. Also permeates anionic liposomes. Has little hemolytic activity. Has an amphiphilic alpha-helix conformation. Shows broad-spectrum antimicrobial activity against the Gram-positive bacteria S.aureus ATCC 6538 (MIC=5 ug/ml), S.saprophyticus CS (MIC=5 ug/ml), S.epidermidis CS (MIC=5 ug/ml), B.subtilis CCT 2471 (MIC=40 ug/ml), and the Gram-negative bacteria E.coli CCT 1371 (MIC=20 ug/ml), E.coli ATCC 25922 (MIC=50 ug/ml), and P.aeruginosa ATCC 15442 (MIC=20 ug/ml). Blocks the lobster neuromuscular transmission. Induces the depolarization of the muscle membrane.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003300    From 1 To 14 E-value: 0.092 Score: 26.6
        INLLKIAKGIIKSL
  • 2. L13A027831    From 1 To 13 E-value: 0.24 Score: 25
        INLLKIAKGIIKS
  • 3. L11A002124    From 1 To 11 E-value: 2.8 Score: 21.6
        LKIAKGIIKSL

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Nakajima T.,Naoki H.,Itagaki Y.,Konno K.,Hisada M.,
  •   Title:Advantages of using nested collision induced dissociation/post-source decay with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: sequencing of novel peptides from wasp venom.
  •   Journal:Rapid Commun. Mass Spectrom., 2000, 14, 1828-1834  [PubMed:11006592]
  •   [2]  Pereira J.H.,Lorenzi C.C.B.,Fadel V.,Delatorre P.,Canduri F.,
  •   Title:Crystallization and preliminary X-ray diffraction analysis of a eumenine mastoparan toxin: a new class of mast-cell degranulating peptide in the wasp venom.
  •   Journal:Acta Crystallogr. D, 2000, 56, 1434-1436  [MEDLINE:20508225]
  •   [3]  Kawai N.,Itagaki Y.,Naoki H.,Hisada M.,Konno K.,
  •   Title:Structure and biological activities of eumenine mastoparan-AF (EMP-AF), a new mast cell degranulating peptide in the venom of the solitary wasp (Anterhynchium flavomarginatum micado).
  •   Journal:Toxicon, 2000, 38, 1505-1515  [MEDLINE:20240153]
  •   [4]  Canduri F.,Lorenzi C.C.B.,Ruggiero Neto J.,Olivieri J.R.,Delatorre P.,
  •   Title:Preliminary cryocrystallography analysis of an eumenine mastoparan toxin isolated from the venom of the wasp Anterhynchium flavomarginatum micado.
  •   Journal:Biochim. Biophys. Acta, 2001, 1545, 372-376  [MEDLINE:21240309]
  •   [5]  Palma M.S.,Konno K.,Fontana R.,de Souza B.M.,dos Santos Cabrera M.P.,
  •   Title:Conformation and lytic activity of eumenine mastoparan: a new antimicrobial peptide from wasp venom.
  •   Journal:J. Pept. Res., 2004, 64, 95-103  [PubMed:15317499]

Comments

  •   Comments

    •     No comments found on LAMP database



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