Record in detail
General Info
- lamp_id:L01A003326
- Name:TACB2_TACTR
- FullName:Tachystatin-B2
- Source:Tachypleus tridentatus
- Mass:4946.6 Da
- Sequence Length:42 aa
- Isoelectric Point:9.45
- Activity:Antibacterial
- Sequence
YITCLFRGARCRVYSGRSCCFGYYCRRDFPGSIFGTCSRRNF - Function:Exhibits stronger antimicrobial activity against the Gram-positive bacteria (S.aureus (IC(50) is 7.4 ug/ml)) and fungi (C.albicans (IC(50) is 3.0 ug/ml) and P.pastoris (IC(50) is 0.1 ug/ml)) than Gram-negative bacteria (E.coli no inhibition at 100 ug/ml). Binds to chitin (4.3 uM are required to obtain 50% of binding). Does not cause hemolysis on sheep erythrocytes. Has no blocking activity on the P-type calcium channel.
Cross-Linking
- Cross-linking
- 1 Database:APD 1006
- 2 Database:CAMP CAMPSQ1074
- 3 Database:dbAMP dbAMP_12204
- 4 Database:DRAMP DRAMP02944
- 5 Database:SATPdb satpdb20486
- 6 Database:Uniprot P0C1Z9
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A003326 From 1 To 42 E-value: 2e-18 Score: 83.2
YITCLFRGARCRVYSGRSCCFGYYCRRDFPGSIFGTCSRRNF - 2. L01A002991 From 1 To 42 E-value: 5e-18 Score: 81.6
YVSCLFRGARCRVYSGRSCCFGYYCRRDFPGSIFGTCSRRNF - 3. L03A000353 From 1 To 42 E-value: 5e-17 Score: 78.2
YVSCLFRGARCEVYSGRSCCFGYYCRRDFPGSYFGTCSRRNF - 4. L03A000161 From 24 To 66 E-value: 0.13 Score: 26.9
YSRCQLQGFNCVVRSYGLPTIPCCRGLTCRSYFPGSTYGRCQR - 5. L12A08087| From 24 To 66 E-value: 0.13 Score: 26.9
YSRCQLQGFNCVVRSYGLPTIPCCRGLTCRSYFPGSTYGRCQR
Activity
- Antibacterial Activities
- 1 Target: S.aureus IC50: 7.4 μg/ml (1.49598 μM)
- 2 Target: P.pastoris IC50: 0.1 μg/ml (0.0202159 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Iwanaga S.,Hirata M.,Nagayama R.,Omotezako M.,Osaki T.,
- Title:Horseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins.
- Journal:J. Biol. Chem., 1999, 274, 26172-26178 [MEDLINE:99403058]
- [2] Osaki T.,Takaya K.,Nakahara T.,Kouno T.,Fujitani N.,
- Title:The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif.
- Journal:J. Pept. Sci., 2007, 13, 269-279 [PubMed:17394123]
Comments
- Comments
No comments found on LAMP database