Record in detail


General Info

  • lamp_id:L01A003346
  • Name:THCL_PLARO
  • FullName:Thiocillin GE2270
  • Source:Planobispora rosea
  • Mass:1412.6 Da
  • Sequence Length:14 aa
  • Isoelectric Point:5.63
  • Activity:Antibacterial
  • Sequence
        SCNCVCGFCCSCSP
  • Function:Has bacteriocidal activity against Gram-positive bacteria and a few Gram-negative bacteria. It is particularly active against anaerobes. Inhibits bacterial protein biosynthesis by preventing the formation of a stable complex between the elongation factor Tu (EF-Tu), GTP and tRNA, hindering the activation of EF-Tu.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003346    From 1 To 14 E-value: 0.019 Score: 28.9
        SCNCVCGFCCSCSP
  • 2. L12A10915|    From 1 To 14 E-value: 0.053 Score: 27.3
        SCNCVCGFCCXCSP
  • 3. L13A025702    From 1 To 12 E-value: 1.4 Score: 22.7
        SCNCVCGVCCSC
  • 4. L12A10916|    From 1 To 10 E-value: 1.9 Score: 22.3
        SCNCVCGFCC
  • 5. L12A06637|    From 35 To 47 E-value: 5.7 Score: 20.8
        SCNCFCYICCSCS

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Gastaldo L.,Saddler G.S.,Montanini N.,Beretta G.,Selva E.,
  •   Title:Antibiotic GE2270 A: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization.
  •   Journal:J. Antibiot., 1991, 44, 693-701  [PubMed:1908853]
  •   [2]  Nebuloni M.,Tavecchia P.,Ferrari P.,Colombo L.,Kettenring J.,
  •   Title:Antibiotic GE2270 A: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation.
  •   Journal:J. Antibiot., 1991, 44, 702-715  [MEDLINE:91349090]
  •   [3]  Bonfichi R.,Sottani C.,Kurz M.,Gentili P.,Tavecchia P.,
  •   Title:Revised structure of the antibiotic GE 2270A.
  •   Journal:J. Antibiot., 1994, 47, 1564-1567  [PubMed:7844053]
  •   [4]  Colombo L.,Tavecchia P.,Kurz M.,Ferrari P.,Selva E.,
  •   Title:Components of the GE2270 complex produced by Planobispora rosea ATCC 53773.
  •   Journal:J. Antibiot., 1995, 48, 1039-1042  [PubMed:7592050]
  •   [5]  Selva E.,Stella S.,Colombo L.,
  •   Title:Contribution of mass spectrometry to the structural confirmation of components of the antibiotic GE2270 complex.
  •   Journal:Rapid Commun. Mass Spectrom., 1995, 9, 717-722  [PubMed:7647369]
  •   [6]  Jurnak F.,Heffron S.E.,
  •   Title:Structure of an EF-Tu complex with a thiazolyl peptide antibiotic determined at 2.35 A resolution: atomic basis for GE2270A inhibition of EF-Tu.
  •   Journal:Biochemistry, 2000, 39, 37-45  [PubMed:10625477]
  •   [7]  Nissen P.,Parmeggiani A.,
  •   Title:Elongation factor Tu-targeted antibiotics: four different structures, two mechanisms of action.
  •   Journal:FEBS Lett., 2006, 580, 4576-4581  [PubMed:16876786]
  •   [8]  Nyborg J.,Nielsen R.C.,Okamura S.,Krab I.M.,Parmeggiani A.,
  •   Title:Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu.
  •   Journal:Biochemistry, 2006, 45, 6846-6857  [PubMed:16734421]
  •   [9]  Bach T.,Delgado O.,Muller H.M.,
  •   Title:Total synthesis of the thiazolyl peptide GE2270 A.
  •   Journal:Angew. Chem. Int. Ed., 2007, 46, 4771-4774  [PubMed:17503407]

Comments

  •   Comments

    •     No comments found on LAMP database



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