Record in detail
General Info
- lamp_id:L01A003369
- Name:ES2HA_RANHO
- FullName:Esculentin-2HSa
- Source:Rana hosii
- Mass:3807.6 Da
- Sequence Length:37 aa
- Isoelectric Point:10.14
- Activity:Antibacterial
- Sequence
GIFSLIKGAAQLIGKTVAKEAGKTGLELMACKVTKQC - Function:Has antibacterial activity against the Gram-positive bacterium S.aureus ATCC 25923 (MIC=32uM) and the Gram-negative bacterium E.coli ATCC 25726 (MIC=16uM).
Cross-Linking
- Cross-linking
- 1 Database:APD 1420
- 2 Database:CAMP CAMPSQ1076
- 3 Database:DBAASP 2216
- 4 Database:dbAMP dbAMP_02862
- 5 Database:DRAMP DRAMP01476
- 6 Database:SATPdb satpdb27962
- 7 Database:Uniprot P0C8T9
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A003369 From 1 To 37 E-value: 0.000000000000003 Score: 72
GIFSLIKGAAQLIGKTVAKEAGKTGLELMACKVTKQC - 2. L12A07355| From 42 To 78 E-value: 0.00000000000008 Score: 67.4
GLFTLIKGAAKLIGKTVAKEAGKTGLELMACKITNQC - 3. L02A001866 From 1 To 37 E-value: 0.00000000000009 Score: 67.4
GIFTLIKGAAKLIGKTVAKEAGKTGLELMACKITNQC - 4. L12A07135| From 42 To 78 E-value: 0.00000000000009 Score: 67.4
GIFSLIKGAAKLITKTVAKEAGKTGLELMACKVTNQC - 5. L12A07340| From 42 To 78 E-value: 0.0000000000001 Score: 67
GLFTLIKGAAKLIGKTVAKEAGKTGLELMACKITHQC
Structure
- Domains
- 1 Name:Antimicrobial_frog_2 Interpro Link:IPR012521
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
- 1 Target: S.aureus ATCC 25923 MIC: 121.84 μg/ml (31.9992 μM)
- 2 Target: E.coli ATCC 25726 MIC: 60.92 μg/ml (15.9996 μM)
- 3 Target: E. coli MIC: 60.9216 μg/ml (16 μM)
- 4 Target: S. aureus MIC: 121.843 μg/ml (32 μM)
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Vaudry H.,Leprince J.,Nowotny N.,Kolodziejek J.,Conlon J.M.,
- Title:Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
- Journal:Toxicon, 2008, 52, 465-473 [PubMed:18621071]
Comments
- Comments
No comments found on LAMP database