Record in detail


General Info

  • lamp_id:L01A003370
  • Name:ES1HA_RANHO
  • FullName:Esculentin-1HSa
  • Source:Rana hosii
  • Mass:4812.7 Da
  • Sequence Length:46 aa
  • Isoelectric Point:10.34
  • Activity:Antibacterial
  • Sequence
        GIFSKFGGKAIKNLFIKGAKNIGKEVGMDVIRTGIDVAGCKIKGEC
  • Function:Has antibacterial activity against the Gram-positive bacterium S.aureus ATCC 25923 (MIC=12uM) and the Gram-negative bacterium E.coli ATCC 25726 (MIC=12uM).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003370    From 1 To 46 E-value: 5e-20 Score: 88.2
        GIFSKFGGKAIKNLFIKGAKNIGKEVGMDVIRTGIDVAGCKIKGEC
  • 2. L12A06987|    From 39 To 84 E-value: 1e-18 Score: 83.6
        GIFSKISGKAIKNLFIKGAKNVGKEVGMDVVRTGIDVVGCKIKGEC
  • 3. L02A001861    From 1 To 46 E-value: 4e-18 Score: 81.6
        GIFSKISGKAIKNLFIKGAKNVGKEVGMDVVRTGIDVVGCKIKGEC
  • 4. L12A06983|    From 39 To 84 E-value: 6e-18 Score: 80.9
        GIFSKFAGKGIKNLLVKGVKNIGKEVGMDVIRTGIDIAGCKIKGEC
  • 5. L102925000    From 1 To 46 E-value: 7e-18 Score: 80.9
        GIFSKISGKAIKNLFIKGAKNVGKEVGMDVVRTGMDVVGCKIKGEC

Structure

  •   Domains

  •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  S.aureus ATCC 25923  MIC:  57.75 μg/ml  (11.9995 μM)  
  •   2  Target:  E.coli ATCC 25726  MIC:  57.75 μg/ml  (11.9995 μM)  
  •   3  Target:  E. coli  MIC:  57.7524 μg/ml  (12 μM)  
  •   4  Target:  S. aureus  MIC:  57.7524 μg/ml  (12 μM)  

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Vaudry H.,Leprince J.,Nowotny N.,Kolodziejek J.,Conlon J.M.,
  •   Title:Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
  •   Journal:Toxicon, 2008, 52, 465-473  [PubMed:18621071]

Comments

  •   Comments

  •     No comments found on LAMP database



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