Record in detail

General Info

lamp_id:L01A003372
Name:NIG2B_RANHO
FullName:Nigrocin-2HSb
Source:Rana hosii
Mass:1979.4 Da
Sequence Length:21 aa
Isoelectric Point:8.82
Activity:Antibacterial
Sequence
GLLGSIFGAGKKIACALSGLC
Function:Has antibacterial activity against the Gram-positive bacterium S.aureus ATCC 25923 (MIC=28uM) and the Gram-negative bacterium E.coli ATCC 25726 (MIC=14uM).

Cross-Linking

Cross-linking
1 Database:APD 1426
2 Database:CAMP CAMPSQ1078
3 Database:DBAASP 2220
4 Database:dbAMP dbAMP_03554
5 Database:DRAMP DRAMP01413
6 Database:SATPdb satpdb11926
7 Database:Uniprot P0C8U1

Top similar AMPs

Top similar AMPs on LAMP
1. L01A003372 From 1 To 21 E-value: 0.00001 Score: 40.4
GLLGSIFGAGKKIACALSGLC
2. L01A003373 From 1 To 21 E-value: 0.00003 Score: 38.9
GLLGSLFGAGKKVACALSGLC
3. L02A001882 From 1 To 21 E-value: 0.004 Score: 31.6
GILGNIVGMGKKIVCGLSGLC
4. L02A001883 From 1 To 21 E-value: 0.005 Score: 31.2
GILGNIVGMGKKVVCGLSGLC
5. L12A03608| From 1 To 21 E-value: 0.006 Score: 31.2
GLLSGILGAGKKIVCGLSGLC

Structure

Domains

Structures

Activity

Antibacterial Activities
1 Target: S.aureus ATCC 25923 MIC: 55.42 μg/ml (27.9984 μM)
2 Target: E.coli ATCC 25726 MIC: 27.71 μg/ml (13.9992 μM)
3 Target: E. coli MIC: 27.7116 μg/ml (14 μM)
4 Target: S. aureus MIC: 55.4232 μg/ml (28 μM)

Toxicity

Toxicity

Reference

Reference
[1] Vaudry H.,Leprince J.,Nowotny N.,Kolodziejek J.,Conlon J.M.,
Title:Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
Journal:Toxicon, 2008, 52, 465-473 [PubMed:18621071]

Comments

Comments