Record in detail

General Info

lamp_id:L01A003373
Name:NIG2A_RANHO
FullName:Nigrocin-2HSa
Source:Rana hosii
Mass:1965.4 Da
Sequence Length:21 aa
Isoelectric Point:8.82
Activity:Antibacterial
Sequence
GLLGSLFGAGKKVACALSGLC
Function:Has antibacterial activity against the Gram-positive bacterium S.aureus ATCC 25923 (MIC=56uM) and the Gram-negative bacterium E.coli ATCC 25726 (MIC=28uM).

Cross-Linking

Cross-linking
1 Database:APD 1425
2 Database:CAMP CAMPSQ1079
3 Database:DBAASP 2219
4 Database:dbAMP dbAMP_03558
5 Database:DRAMP DRAMP01412
6 Database:SATPdb satpdb18609
7 Database:Uniprot P0C8U0

Top similar AMPs

Top similar AMPs on LAMP
1. L01A003373 From 1 To 21 E-value: 0.00001 Score: 40
GLLGSLFGAGKKVACALSGLC
2. L01A003372 From 1 To 21 E-value: 0.00003 Score: 38.9
GLLGSIFGAGKKIACALSGLC
3. L02A001883 From 1 To 21 E-value: 0.007 Score: 30.8
GILGNIVGMGKKVVCGLSGLC
4. L02A001882 From 1 To 21 E-value: 0.009 Score: 30.4
GILGNIVGMGKKIVCGLSGLC
5. L02A001885 From 1 To 21 E-value: 0.014 Score: 30
GILGNIVGMGKQVVCGLSGLC

Structure

Domains

Structures

Activity

Antibacterial Activities
1 Target: S.aureus ATCC 25923 MIC: 110.06 μg/ml (55.9988 μM)
2 Target: E.coli ATCC 25726 MIC: 55.03 μg/ml (27.9994 μM)
3 Target: E. coli MIC: 55.0312 μg/ml (28 μM)
4 Target: S. aureus MIC: 110.062 μg/ml (56 μM)

Toxicity

Toxicity

Reference

Reference
[1] Vaudry H.,Leprince J.,Nowotny N.,Kolodziejek J.,Conlon J.M.,
Title:Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
Journal:Toxicon, 2008, 52, 465-473 [PubMed:18621071]

Comments

Comments