Record in detail


General Info

  • lamp_id:L01A003374
  • Name:THCL_STRAJ
  • FullName:Thiostrepton
  • Source:Streptomyces azureus
  • Mass:1640.8 Da
  • Sequence Length:17 aa
  • Isoelectric Point:5.63
  • Activity:Antibacterial
  • Sequence
        IASASCTTCICTCSCSS
  • Function:Has bacteriocidal activity. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu) (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A06590|    From 56 To 72 E-value: 0.002 Score: 32.7
        IASASCTTCICTCSCSS
  • 2. L01A003374    From 1 To 17 E-value: 0.009 Score: 30
        IASASCTTCICTCSCSS

Structure

  •   Domains
  •   1  Name:Thiopep_bacteriocin_prcur    Interpro Link:IPR023895
  •   Structures

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Weinstein M.J.,Stout H.A.,Pagano J.F.,Donovick R.,
  •   Title:Thiostrepton, a new antibiotic. I. In vitro studies.
  •   Journal:Antibiot. Annu., 1955, 3, 554-559  [PubMed:13355325]
  •   [2]  Vandeputte J.,Dutcher J.D.,
  •   Title:Thiostrepton, a new antibiotic. II. Isolation and chemical characterization.
  •   Journal:Antibiot. Annu., 1955, 3, 560-561  [PubMed:13355326]
  •   [3]  Suydam L.O.,Steinberg B.A.,Jambor W.P.,
  •   Title:Thiostrepton, a new antibiotic. III. In vivo studies.
  •   Journal:Antibiot. Annu., 1955, 3, 562-565  [PubMed:13355327]
  •   [4]  Albers-Schonberg G.,Hensens O.D.,
  •   Title:13C NMR study of thiostrepton and thiopeptin components.
  •   Journal:J. Antibiot., 1983, 36, 832-845  [PubMed:6885637]
  •   [5]  Anderson B.F.,Albers-Schonberg G.,Hensens O.D.,
  •   Title:The solution conformation of the peptide antibiotic thiostrepton: a 1H NMR study.
  •   Journal:J. Antibiot., 1983, 36, 799-813  [PubMed:6885635]
  •   [6]  Floss H.G.,Shipley P.R.,Smith T.M.,Priestley N.D.,
  •   Title:Studies on the biosynthesis of thiostrepton: 4-(1-hydroxyethyl)quinoline-2-carboxylate as a free intermediate on the pathway to the quinaldic acid moiety.
  •   Journal:Bioorg. Med. Chem., 1996, 4, 1135-1147  [PubMed:8831986]
  •   [7]  Hunter W.N.,Alphey M.S.,Shaw M.P.,Bond C.S.,
  •   Title:Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur.
  •   Journal:Acta Crystallogr. D, 2001, 57, 755-758  [PubMed:11320328]
  •   [8]  Lee S.H.,Estrada A.A.,Safina B.S.,Zak M.,Nicolaou K.C.,
  •   Title:Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis.
  •   Journal:J. Am. Chem. Soc., 2005, 127, 11176-11183  [PubMed:16076225]
  •   [9]  Nevalainen M.,Lee S.H.,Zak M.,Safina B.S.,Nicolaou K.C.,
  •   Title:Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks.
  •   Journal:J. Am. Chem. Soc., 2005, 127, 11159-11175  [PubMed:16076224]
  •   [10]  Memmert K.,Oberer L.,Naegeli H.U.,Leeds J.A.,Morris R.P.,
  •   Title:Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.
  •   Journal:J. Am. Chem. Soc., 2009, 131, 5946-5955  [PubMed:19338336]

Comments

  •   Comments

    •     No comments found on LAMP database



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