Record in detail

General Info

lamp_id:L01A003384
Name:BR1PA_RANPC
FullName:Brevinin-1PTa
Source:Rana picturata
Mass:2499.1 Da
Sequence Length:24 aa
Isoelectric Point:10.06
Activity:Antibacterial
Sequence
FMGGLIKAATKIVPAAYCAITKKC
Function:Has antibacterial activity against the Gram-positive bacterium S.aureus ATCC 25923 (MIC=3uM) and the Gram-negative bacterium E.coli ATCC 25726 (MIC=24uM).

Cross-Linking

Cross-linking
1 Database:APD 1432
2 Database:CAMP CAMPSQ1085
3 Database:DBAASP 2221
4 Database:dbAMP dbAMP_02249
5 Database:DRAMP DRAMP01951
6 Database:SATPdb satpdb16813
7 Database:Uniprot P0C8T1

Top similar AMPs

Top similar AMPs on LAMP
1. L01A003384 From 1 To 24 E-value: 0.00000003 Score: 48.9
FMGGLIKAATKIVPAAYCAITKKC
2. L01A003383 From 1 To 24 E-value: 0.0000006 Score: 44.7
FMGGLIKAATKALPAAFCAITKKC
3. L12A07100| From 42 To 65 E-value: 0.00008 Score: 37.4
FLGALFKVASKVLPSVFCAITKKC
4. L01A000306 From 1 To 24 E-value: 0.0001 Score: 37
FLGALFKVASKVLPSVFCAITKKC
5. L03A000019 From 1 To 24 E-value: 0.0006 Score: 34.7
FLGALFKVASKVLPSVKCAITKKC

Structure

Domains
1 Name:Antimicrobial_frog_1 Interpro Link:IPR012520

Structures

Activity

Antibacterial Activities
1 Target: S.aureus ATCC 25923 MIC: 7.5 μg/ml (3.00108 μM)
2 Target: E.coli ATCC 25726 MIC: 59.98 μg/ml (24.0006 μM)
3 Target: E. coli MIC: 59.9784 μg/ml (24 μM)
4 Target: S. aureus MIC: 7.4973 μg/ml (3 μM)

Toxicity

Toxicity

Reference

Reference
[1] Vaudry H.,Leprince J.,Nowotny N.,Kolodziejek J.,Conlon J.M.,
Title:Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
Journal:Toxicon, 2008, 52, 465-473 [PubMed:18621071]

Comments

Comments