Record in detail

General Info

lamp_id:L01A003385
Name:BR1HB_RANHO
FullName:Brevinin-1HSb
Source:Rana hosii
Mass:2561.2 Da
Sequence Length:24 aa
Isoelectric Point:9.76
Activity:Antibacterial
Sequence
FLPAVLRVAAQVVPTVFCAISKKC
Function:Has antibacterial activity against the Gram-positive bacterium S.aureus ATCC 25923 (MIC=3uM) and the Gram-negative bacterium E.coli ATCC 25726 (MIC>48uM).

Cross-Linking

Cross-linking
1 Database:APD 1424
2 Database:CAMP CAMPSQ1086
3 Database:DBAASP 2218
4 Database:dbAMP dbAMP_01993
5 Database:DRAMP DRAMP01950
6 Database:SATPdb satpdb11368
7 Database:Uniprot P0C8S8

Top similar AMPs

Top similar AMPs on LAMP
1. L01A003385 From 1 To 24 E-value: 0.00000005 Score: 48.1
FLPAVLRVAAQVVPTVFCAISKKC
2. L01A003386 From 1 To 24 E-value: 0.0000002 Score: 46.2
FLPAVLRVAAKIVPTVFCAISKKC
3. L12A07142| From 47 To 70 E-value: 0.0000002 Score: 46.2
FLPAVIRVAANVLPTVFCAISKKC
4. L12A07215| From 47 To 70 E-value: 0.0000003 Score: 45.4
FLPAVIRVAANVLPTVFCAISKKC
5. L12A06949| From 47 To 70 E-value: 0.0000003 Score: 45.4
FLPAVIRVAANVLPTVFCAISKKC

Structure

Domains
1 Name:Antimicrobial_frog_1 Interpro Link:IPR012520

Structures

Activity

Antibacterial Activities
1 Target: E. coli MIC: 122.938 μg/ml (48 μM)
2 Target: S. aureus MIC: 7.6836 μg/ml (3 μM)

Toxicity

Toxicity

Reference

Reference
[1] Vaudry H.,Leprince J.,Nowotny N.,Kolodziejek J.,Conlon J.M.,
Title:Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
Journal:Toxicon, 2008, 52, 465-473 [PubMed:18621071]

Comments

Comments