Record in detail

General Info

lamp_id:L01A003386
Name:BR1HA_RANHO
FullName:Brevinin-1HSa
Source:Rana hosii
Mass:2575.2 Da
Sequence Length:24 aa
Isoelectric Point:10.51
Activity:Antibacterial
Sequence
FLPAVLRVAAKIVPTVFCAISKKC
Function:Has antibacterial activity against the Gram-positive bacterium S.aureus ATCC 25923 (MIC=3uM) and the Gram-negative bacterium E.coli ATCC 25726 (MIC=24uM).

Cross-Linking

Cross-linking
1 Database:APD 1423
2 Database:CAMP CAMPSQ1087
3 Database:DBAASP 2217
4 Database:dbAMP dbAMP_01990
5 Database:DRAMP DRAMP01949
6 Database:SATPdb satpdb14855
7 Database:Uniprot P0C8S7

Top similar AMPs

Top similar AMPs on LAMP
1. L01A003386 From 1 To 24 E-value: 0.00000007 Score: 47.8
FLPAVLRVAAKIVPTVFCAISKKC
2. L01A003385 From 1 To 24 E-value: 0.0000002 Score: 46.2
FLPAVLRVAAQVVPTVFCAISKKC
3. L12A07142| From 47 To 70 E-value: 0.0000003 Score: 45.4
FLPAVIRVAANVLPTVFCAISKKC
4. L13A024191 From 1 To 24 E-value: 0.0000004 Score: 45.1
FLPAVLRVAAKVVPTVFCLISKKC
5. L12A07215| From 47 To 70 E-value: 0.0000005 Score: 44.7
FLPAVIRVAANVLPTVFCAISKKC

Structure

Domains
1 Name:Antimicrobial_frog_1 Interpro Link:IPR012520

Structures

Activity

Antibacterial Activities
1 Target: E. coli MIC: 61.8048 μg/ml (24 μM)
2 Target: S. aureus MIC: 7.7256 μg/ml (3 μM)

Toxicity

Toxicity

Reference

Reference
[1] Vaudry H.,Leprince J.,Nowotny N.,Kolodziejek J.,Conlon J.M.,
Title:Characterization of antimicrobial peptides from the skin secretions of the Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).
Journal:Toxicon, 2008, 52, 465-473 [PubMed:18621071]

Comments

Comments