Record in detail


General Info

  • lamp_id:L01A003388
  • Name:H1_SALSA
  • FullName:Histone H1
  • Source:Salmo salar
  • Mass:2794.3 Da
  • Sequence Length:30 aa
  • Isoelectric Point:11.2
  • Activity:Antibacterial
  • Sequence
        AEVAPAPAAAAPAKAPKKKAAAKPKKAGPS
  • Function:Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A06167|    From 2 To 31 E-value: 0.00000006 Score: 48.1
        AEVAPAPAAAAPAKAPKKKAAAKPKKAGPS
  • 2. L01A003388    From 1 To 30 E-value: 0.0000002 Score: 46.2
        AEVAPAPAAAAPAKAPKKKAAAKPKKAGPS

Structure

  •   Domains
  •   1  Name:Histone_H1/H5    Interpro Link:IPR005818
  •   2  Name:WHTH_trsnscrt_rep_DNA-bd    Interpro Link:IPR011991
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E.coli  MIC:  5.59 μg/ml  (2.0005 μM)  
  •   2  Target:  A.salmonicida subsp salmonicida  MIC:  11.18 μg/ml  (4.001 μM)  
  •   3  Target:  V.anguillarum  MIC:  2.79 μg/ml  (0.998461 μM)  
  •   4  Target:  S.typhimurium  MIC:  11.18 μg/ml  (4.001 μM)  
  •   5  Target:  B.subtilis  MIC:  5.59 μg/ml  (2.0005 μM)  
  •   6  Target:  L.ivanovii  MIC:  11.18 μg/ml  (4.001 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Nes I.F.,Andersen O.,Nissen-Meyer J.,Birkemo G.A.,Luders T.,
  •   Title:Proline conformation-dependent antimicrobial activity of a proline-rich histone H1 N-terminal peptide fragment isolated from the skin mucus of Atlantic salmon.
  •   Journal:Antimicrob. Agents Chemother., 2005, 49, 2399-2406  [PubMed:15917539]

Comments

  •   Comments

    •     No comments found on LAMP database



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