Record in detail

lamp_id:L01A003395
Name:MOR1_BOMMO
FullName:Moricin-1
Source:Bombyx mori
Mass:4543.5 Da
Sequence Length:42 aa
Isoelectric Point:12.03
Activity:Antibacterial
Sequence
AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH
Function:Has antibacterial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.

Top similar AMPs on LAMP
1. L03A000230 From 25 To 66 E-value: 1e-18 Score: 83.2
AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH
2. L01A002637 From 13 To 54 E-value: 1e-18 Score: 83.2
AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH
3. L12A08784| From 25 To 66 E-value: 2e-18 Score: 83.2
AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH
4. L01A003395 From 1 To 42 E-value: 4e-18 Score: 82
AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH
5. L01A002650 From 1 To 42 E-value: 6e-18 Score: 81.3
AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLEPKKRKH

Antibacterial Activities
1 Target: E. coli JM109 MIC: 1.41 μg/ml (0.310333 μM)
2 Target: Acinetobacter sp. NISL B-4653 MIC: 1.23 μg/ml (0.270716 μM)
3 Target: Pseudomonas fluorescens IAM1179 MIC: 2.41 μg/ml (0.530428 μM)
4 Target: Pseudomonas aeruginosa IAM15140 MIC: 3.68 μg/ml (0.809948 μM)
5 Target: Bacillus subtilis IAM1107 MIC: 0.86 μg/ml (0.189281 μM)
6 Target: Bacillus megaterium IAM1030 MIC: 0.41 μg/ml (0.0902388 μM)
7 Target: B. cereus IFO3457 MIC: 1.73 μg/ml (0.380764 μM)
8 Target: S. aureus ATCC6538P MIC: 0.95 μg/ml (0.20909 μM)
9 Target: S. aureus ATCC6538P MIC: 1 μg/ml (0.220095 μM)
10 Target: S. aureus IFO3083 MIC: 2.09 μg/ml (0.459998 μM)
11 Target: Staphylococcus xylosus IAM1312 MIC: 1.23 μg/ml (0.270716 μM)
12 Target: Staphylococcus epidermidis IFO12993 MIC: 0.82 μg/ml (0.180478 μM)
13 Target: S. pyogenes ATCC21547 MIC: 1.14 μg/ml (0.250908 μM)

Reference
[1] Yamakawa M.,Hara S.,
Title:Moricin, a novel type of antibacterial peptide isolated from the silkworm, Bombyx mori.
Journal:J. Biol. Chem., 1995, 270, 29923-29927 [MEDLINE:96102048]
[2] Shono T.,Ishibashi J.,Nakazawa H.,Tanaka H.,Furukawa S.,
Title:Inducible gene expression of moricin, a unique antibacterial peptide from the silkworm (Bombyx mori).
Journal:Biochem. J., 1999, 340, 265-271 [MEDLINE:99247919]
[3] Yamakawa M.,Hara S.,Ishibashi J.,Hemmi H.,
Title:Solution structure of moricin, an antibacterial peptide, isolated from the silkworm Bombyx mori.
Journal:FEBS Lett., 2002, 518, 33-38 [MEDLINE:21992780]