Record in detail


General Info

  • lamp_id:L01A003435
  • Name:COLUA_COLDE
  • FullName:Colutellin-A
  • Source:Colletotrichum dematium
  • Mass:739.9 Da
  • Sequence Length:7 aa
  • Isoelectric Point:6.02
  • Activity:Antifungal
  • Sequence
        VISIIPV
  • Function:Has antifungal activity against S.sclerotiorum (MIC=32.4 ug/ml after 288 hours) and B.cinerea (MIC=10.8 ug/ml after 288 hours), and weak antifungal activity against F.solani, A.fumigatus and G.candidum. Lacks antifungal activity against P.ultimum, T.viride and R.solani. Inhibits the production of interleukin-2 by activated CD4+ T-cells with an IC(50) of 167.3 nM. Lacks cytotoxic activity against human peripheral blood mononuclear cells.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP

    •     No similar AMPs found on LAMP database

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  S.sclerotiorum  MIC:  288 μg/ml  (389.242 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Park S.G.,Jutila M.,Graff J.C.,Strobel G.A.,Ren Y.,
  •   Title:Colutellin A, an immunosuppressive peptide from Colletotrichum dematium.
  •   Journal:Microbiology, 2008, 154, 1973-1979  [PubMed:18599825]

Comments

  •   Comments

    •     No comments found on LAMP database



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