Record in detail


General Info

  • lamp_id:L01A003454
  • Name:THCL_STRSQ
  • FullName:Thiocillin GE37468
  • Source:Streptomyces sp.
  • Mass:1504.7 Da
  • Sequence Length:14 aa
  • Isoelectric Point:5.63
  • Activity:Antibacterial
  • Sequence
        STNCFCYPCCSCSS
  • Function:Has bacteriocidal activity against both aerobic and anaerobic Gram-positive bacteria. Inhibits growth of B.subtilis (MIC=0.047 ug/ml) and methicillin-resistant S.aureus (MRSA) (MIC=0.047 ug/ml). Has poor activity against Gram-negative bacteria, with the exception of B.fragilis. Inhibits bacterial protein biosynthesis by acting on elongation factor Tu (EF-Tu). Full antibiotic activity depends on the presence of the modified residue Ile-50.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003454    From 1 To 14 E-value: 0.015 Score: 29.3
        STNCFCYPCCSCSS
  • 2. L12A07427|    From 43 To 56 E-value: 0.028 Score: 28.1
        STNCFCYICCSCSS
  • 3. L12A06637|    From 37 To 48 E-value: 0.23 Score: 25
        NCFCYICCSCSS

Structure

  •   Domains

  •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

  •     No MICs found on LAMP database

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Colombo L.,Ferrari P.,Le Monnier F.,Montanini N.,Stella S.,
  •   Title:Antibiotic GE37468 A: a new inhibitor of bacterial protein synthesis. I. Isolation and characterization.
  •   Journal:J. Antibiot., 1995, 48, 780-786  [PubMed:7592021]
  •   [2]  Zerilli L.F.,Selva E.,Stella S.,Colombo L.,Ferrari P.,
  •   Title:Antibiotic GE37468 A: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation.
  •   Journal:J. Antibiot., 1995, 48, 1304-1311  [PubMed:8557573]
  •   [3]  Walsh C.T.,Young T.S.,
  •   Title:Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans.
  •   Journal:Proc. Natl. Acad. Sci. U.S.A., 2011, 108, 13053-13058  [PubMed:21788474]

Comments

  •   Comments

  •     No comments found on LAMP database



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