Record in detail
General Info
- lamp_id:L01A003454
- Name:THCL_STRSQ
- FullName:Thiocillin GE37468
- Source:Streptomyces sp.
- Mass:1504.7 Da
- Sequence Length:14 aa
- Isoelectric Point:5.63
- Activity:Antibacterial
- Sequence
STNCFCYPCCSCSS - Function:Has bacteriocidal activity against both aerobic and anaerobic Gram-positive bacteria. Inhibits growth of B.subtilis (MIC=0.047 ug/ml) and methicillin-resistant S.aureus (MRSA) (MIC=0.047 ug/ml). Has poor activity against Gram-negative bacteria, with the exception of B.fragilis. Inhibits bacterial protein biosynthesis by acting on elongation factor Tu (EF-Tu). Full antibiotic activity depends on the presence of the modified residue Ile-50.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ1878
- 2 Database:dbAMP dbAMP_11270
- 3 Database:DRAMP DRAMP00204
- 4 Database:SATPdb satpdb26297
- 5 Database:Uniprot P0C8P9
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A003454 From 1 To 14 E-value: 0.015 Score: 29.3
STNCFCYPCCSCSS - 2. L12A07427| From 43 To 56 E-value: 0.028 Score: 28.1
STNCFCYICCSCSS - 3. L12A06637| From 37 To 48 E-value: 0.23 Score: 25
NCFCYICCSCSS
Structure
- Domains
No domains found on LAMP database
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Colombo L.,Ferrari P.,Le Monnier F.,Montanini N.,Stella S.,
- Title:Antibiotic GE37468 A: a new inhibitor of bacterial protein synthesis. I. Isolation and characterization.
- Journal:J. Antibiot., 1995, 48, 780-786 [PubMed:7592021]
- [2] Zerilli L.F.,Selva E.,Stella S.,Colombo L.,Ferrari P.,
- Title:Antibiotic GE37468 A: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation.
- Journal:J. Antibiot., 1995, 48, 1304-1311 [PubMed:8557573]
- [3] Walsh C.T.,Young T.S.,
- Title:Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans.
- Journal:Proc. Natl. Acad. Sci. U.S.A., 2011, 108, 13053-13058 [PubMed:21788474]
Comments
- Comments
No comments found on LAMP database