Record in detail


General Info

  • lamp_id:L01A003460
  • Name:MICA_CLAMM
  • FullName:Lantibiotic michiganin-A
  • Source:Clavibacter michiganensis subsp. michiganensis
  • Mass:2217.6 Da
  • Sequence Length:21 aa
  • Isoelectric Point:6.07
  • Activity:Antibacterial
  • Sequence
        SSSGWLCTLTIECGTIICACR
  • Function:Lanthionine-containing peptide antibiotic (lantibiotic) active aganist S.michiganensis subspecies sepedonicus strain 2136 (MIC=30 pmol/ml). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A08515|    From 48 To 68 E-value: 0.0000003 Score: 45.4
        SSSGWLCTLTIECGTIICACR
  • 2. L01A003460    From 1 To 21 E-value: 0.000002 Score: 42.7
        SSSGWLCTLTIECGTIICACR
  • 3. L12A00066|    From 2 To 22 E-value: 0.000007 Score: 40.8
        ASSGWVCTLTIECGTVICACR
  • 4. L13A011450    From 1 To 21 E-value: 0.000008 Score: 40.8
        ASSGWVCTLTIECGTVICACR
  • 5. L12A09280|    From 45 To 64 E-value: 0.00001 Score: 39.7
        ASSGWVCTLTIECGTVICAC

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  S.michiganensis subspecies sepedonicus strain 2136  MIC:  30 μg/ml  (13.5281 μM)  

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Brurberg M.B.,Eijsink V.G.,Mantzilas D.,Holtsmark I.,
  •   Title:Purification, characterization, and gene sequence of michiganin A, an actagardine-like lantibiotic produced by the tomato pathogen Clavibacter michiganensis subsp. michiganensis.
  •   Journal:Appl. Environ. Microbiol., 2006, 72, 5814-5821  [PubMed:16957199]

Comments

  •   Comments

    •     No comments found on LAMP database



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