Record in detail
General Info
- lamp_id:L01A003466
- Name:GRA4A_POGPU
- FullName:Grammistin Pp 4a
- Source:Pogonoperca punctata
- Mass:2569.2 Da
- Sequence Length:24 aa
- Isoelectric Point:10.55
- Activity:Antibacterial
- Sequence
LFGFLIPLLPHIIGAIPQVIGAIR - Function:Thanks to its abundant amphiphilic alpha-helices, it may integrate into membrane phospholipids, leading to lysis of the membrane. Its high hemolytic activity is inhibited by phospholipids, but not by cholesterol. Has antibacterial activity with a broad spectrum against various species of bacteria including both Gram-positive and Gram-negative groups. Has also high ichthyotoxic activity (By similarity).
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ1096
- 2 Database:DBAASP 3334
- 3 Database:dbAMP dbAMP_05723
- 4 Database:DRAMP DRAMP02377
- 5 Database:SATPdb satpdb18280
- 6 Database:Uniprot P69837
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L01A003466 From 1 To 24 E-value: 0.0000002 Score: 46.6
LFGFLIPLLPHIIGAIPQVIGAIR - 2. L01A003465 From 1 To 24 E-value: 0.0000003 Score: 45.4
LFGFLIPLLPHLIGAIPQVIGAIR - 3. L01A003470 From 1 To 19 E-value: 0.37 Score: 25.4
LFGFLIKLIPSLFGALSNI - 4. L11A004077 From 1 To 21 E-value: 2.6 Score: 22.3
FIKELLPHLSGIIDSVANAIK - 5. L10G0LWV90 From 1 To 21 E-value: 2.6 Score: 22.3
FIKELLPHLSGIIDSVANAIK
Structure
- Domains
No domains found on LAMP database
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Ishida M.,Nagashima Y.,Yokota H.,Shiomi K.,
- Title:Primary and secondary structures of grammistins, peptide toxins isolated from the skin secretion of the soapfish Pogonoperca punctata.
- Journal:Fish. Sci., 2001, 67, 163-169 [DOI:10.1046/j.1444-2906.2001.00213.x]
Comments
- Comments
No comments found on LAMP database