Record in detail


General Info

  • lamp_id:L01A003548
  • Name:WAPA_OXYMI
  • FullName:Omwaprin-a
  • Source:Oxyuranus microlepidotus
  • Mass:5610.5 Da
  • Sequence Length:50 aa
  • Isoelectric Point:8.4
  • Activity:Antibacterial
  • Sequence
        KDRPKKPGLCPPRPQKPCVKECKNDDSCPGQQKCCNYGCKDECRDPIFVG
  • Function:Damages membranes of susceptible bacteria. Has antibacterial activity against the Gram-positive bacteria B.megaterium and S.warneri. Has no antibacterial activity against the Gram-positive bacteria B.thuringiensis, S.aureus and S.clavuligerus, or the Gram-negative bacteria E.coli and A.tumefaciens. Has no hemolytic activity. Not toxic to mice. Does not inhibit the proteinases elastase and cathepsin G.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003548    From 1 To 50 E-value: 5e-23 Score: 97.8
        KDRPKKPGLCPPRPQKPCVKECKNDDSCPGQQKCCNYGCKDECRDPIFVG
  • 2. L13A022979    From 1 To 50 E-value: 4e-21 Score: 91.7
        KDRPKKPGLCPPRPQKPCVKECKNDWSCPGQQKCCNYGCIDECRDPIFVN
  • 3. L12A09833|    From 7 To 61 E-value: 0.0003 Score: 35.4
        KPTPSKPGYCRVMDELILCPDPPLSKDLCKNDSDCPGAQKCCYRTCIMQCLPPIF
  • 4. L01A003583    From 51 To 94 E-value: 0.004 Score: 32
        PVLPWSCPRNPFKCTIPGIDRCRYDYDCPGRQRCCYYSCSRICK
  • 5. L01A003583    From 24 To 50 E-value: 0.13 Score: 26.9
        NRCRRDYDCPQTLRCCNFRCSRSCRIP

Structure

  •   Domains
  •   1  Name:4-disulphide_core    Interpro Link:IPR015874
  •   2  Name:Whey_acidic_protein_4-diS_core    Interpro Link:IPR008197
  •   Structures
  •   1
    PDB:3NGG
    Method:X-ray
    Chains:A/B=1-50

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Kini R.M.,Kumar P.P.,Alewood P.F.,Fry B.G.,Nair D.G.,
  •   Title:Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins.
  •   Journal:Biochem. J., 2007, 402, 93-104  [PubMed:17044815]

Comments

  •   Comments

    •     No comments found on LAMP database



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