Record in detail


General Info

  • lamp_id:L01A003735
  • Name:OXLA_PROFL
  • FullName:L-amino-acid oxidase
  • Source:Protobothrops flavoviridis
  • Mass:2573.7 Da
  • Sequence Length:20 aa
  • Isoelectric Point:3.99
  • Activity:Antibacterial
  • Sequence
        AHDRNPLEEYFRETDYEEFL
  • Function:Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as hemorrhage, edema, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions (By similarity). This protein has an ability to induce hemolysis and apoptosis.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003735    From 1 To 20 E-value: 0.000001 Score: 43.1
        AHDRNPLEEYFRETDYEEFL
  • 2. L01A003738    From 1 To 20 E-value: 0.00001 Score: 40
        ADDRNPLEQCFRETDYEEFL
  • 3. L13A010532    From 1 To 20 E-value: 0.00003 Score: 38.5
        ADDRNPLEQCFRETDYEEFL
  • 4. L01A003734    From 1 To 20 E-value: 0.0009 Score: 33.9
        ADNKNPLEECFRETNYEEFL
  • 5. L01A003737    From 1 To 20 E-value: 0.001 Score: 33.5
        ADDKNPLEEAFREADYEVFL

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Nagata N.,Ito J.,Munakata H.,Shimoyama Y.,Abe Y.,
  •   Title:Characterization of an apoptosis-inducing factor in Habu snake venom as a glycyrrhizin (GL)-binding protein potently inhibited by GL in vitro.
  •   Journal:Biol. Pharm. Bull., 1998, 21, 924-927  [PubMed:9781840]
  •   [2]  Saito A.,Tsurushima H.,Hyodo A.,Yoshii Y.,Sun L.-K.,
  •   Title:Apoptotic effect in the glioma cells induced by specific protein extracted from Okinawa Habu (Trimeresurus flavoviridis) venom in relation to oxidative stress.
  •   Journal:Toxicol. in Vitro, 2003, 17, 169-177  [PubMed:12650671]

Comments

  •   Comments

    •     No comments found on LAMP database



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