Record in detail

lamp_id:L01A003739
Name:OXLA_BOTPI
FullName:L-amino-acid oxidase
Source:Bothrops pirajai
Mass:5298.9 Da
Sequence Length:49 aa
Isoelectric Point:4.86
Activity:Antibacterial, ,Anticancer
Sequence
ADDKNPLEEFRETNYEVFLEIAKNGLKATSNPKRVVIVGAGMAGLSAAY
Function:Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Exhibits diverse biological activities, such as edema, antibacterial (E.coli, and P.aeruginosa) and antiparasitic activities, as well as induction of platelet aggregation. Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation. These different effects are probably due to different experimental conditions. This protein may also have activities in hemorrhage, hemolysis, and apoptosis.

Top similar AMPs on LAMP
1. L01A003739 From 1 To 49 E-value: 7e-24 Score: 100
ADDKNPLEEFRETNYEVFLEIAKNGLKATSNPKRVVIVGAGMAGLSAAY
2. L01A003738 From 1 To 50 E-value: 4e-19 Score: 85.1
ADDRNPLEQCFRETDYEEFLEIARNNLKATSNPKHVVIVGAGMAGLSAAY
3. L13A010532 From 1 To 50 E-value: 5e-19 Score: 84.7
ADDRNPLEQCFRETDYEEFLEIARNNLKATSNPKHVVIVGAGMAGLSAAY
4. L01A003736 From 2 To 38 E-value: 0.00000006 Score: 48.1
DRRSPLEECFQQNDYEEFLEIAKNGLKKTXNPKHVXV
5. L01A003737 From 1 To 27 E-value: 0.00000006 Score: 47.8
ADDKNPLEEAFREADYEVFLEIAKNGL

Reference
[1] Hamaguchi A.,Sant"Ana C.D.,Souza G.R.L.,Ribeiro M.C.,Izidoro L.F.M.,
Title:Biochemical and functional characterization of an L-amino acid oxidase isolated from Bothrops pirajai snake venom.
Journal:Bioorg. Med. Chem., 2006, 14, 7034-7043 [PubMed:16809041]