Record in detail


General Info

  • lamp_id:L01A003745
  • Name:OXLA_OPHHA
  • FullName:L-amino-acid oxidase
  • Source:Ophiophagus hannah
  • Mass:2298.4 Da
  • Sequence Length:19 aa
  • Isoelectric Point:4.02
  • Activity:Antibacterial
  • Sequence
        HVINLEESFQEPEYENHLA
  • Function:Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Unlike most snake L-amino-acid oxidases, this enzyme exhibits potent activity against L-Lys. Has also potent activity against L-Met, L-Leu, L-His, L-Lys and L-Ile. Its activity on platelet aggregation is controversial. It has potent inhibitory activity on platelet aggregation induced by ADP and the thromboxane analog U46619, but not by thrombin, mucetin, ristocetin and stejnulxin (PubMed:17543361), but it has also been shown to induce platelet aggregation through the formation of hydrogen peroxide (PubMed:7886693). It binds to bacteria and shows antibacterial activities by generating hydrogen peroxide. Binding and antibacterial activities are higher against Gram-positive than against Gram-negative bacteria. May also have an ability to induce hemorrhage, hemolysis, edema, apoptosis.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003745    From 1 To 19 E-value: 0.000009 Score: 40.4
        HVINLEESFQEPEYENHLA

Structure

  •   Domains
  •   1  Name:Amino_oxidase    Interpro Link:IPR002937
  •   2  Name:Flavin_amine_oxidase    Interpro Link:IPR001613
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Saifuddin M.N.,Tan N.H.,
  •   Title:Isolation and characterization of an unusual form of L-amino acid oxidase from King cobra (Ophiophagus hannah) venom.
  •   Journal:Biochem. Int., 1989, 19, 937-944  [PubMed:2619759]
  •   [2]  Saifuddin M.N.,Tan N.H.,
  •   Title:Substrate specificity of king cobra (Ophiophagus hannah) venom L-amino acid oxidase.
  •   Journal:Int. J. Biochem., 1991, 23, 323-327  [PubMed:2044840]
  •   [3]  Lian E.C.,Yu T.F.,Li Z.Y.,
  •   Title:Purification and characterization of L-amino acid oxidase from king cobra (Ophiophagus hannah) venom and its effects on human platelet aggregation.
  •   Journal:Toxicon, 1994, 32, 1349-1358  [PubMed:7886693]
  •   [4]  Tan N.-H.,Chung M.C.M.,Ponnudurai G.,
  •   Title:Purification and properties of the L-amino acid oxidase from Malayan pit viper (Calloselasma rhodostoma) venom.
  •   Journal:Arch. Biochem. Biophys., 1994, 313, 373-378  [MEDLINE:94361525]
  •   [5]  Choy S.-K.,Tan N.-H.,
  •   Title:The edema inducing activity of Ophiophagus hannah (king cobra) venom L-amino acid oxidase.
  •   Journal:Toxicon, 1994, 32, 539-539  [:]
  •   [6]  Kim Y.S.,Lee B.M.,Ahn M.Y.,
  •   Title:Characterization and cytotoxicity of L-amino acid oxidase from the venom of king cobra (Ophiophagus hannah).
  •   Journal:Int. J. Biochem. Cell Biol., 1997, 29, 911-919  [MEDLINE:97449790]
  •   [7]  Zhang Y.,Zeng L.,Lee W.-H.,Jin Y.,
  •   Title:Molecular characterization of L-amino acid oxidase from king cobra venom.
  •   Journal:Toxicon, 2007, 50, 479-489  [PubMed:17543361]
  •   [8]  Sekaran S.D.,Fung S.Y.,Tan N.H.,Lee M.L.,
  •   Title:Antibacterial action of a heat-stable form of L-amino acid oxidase isolated from king cobra (Ophiophagus hannah) venom.
  •   Journal:Comp. Biochem. Physiol., 2011, 153, 237-242  [PubMed:21059402]

Comments

  •   Comments

    •     No comments found on LAMP database



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