Record in detail

lamp_id:L02A000009
Name:CTHL2_BOVIN
FullName:Cathelicidin-2
Source:Bos taurus
Mass:5148.2 Da
Sequence Length:43 aa
Isoelectric Point:13.04
Activity:Antibacterial,Antifungal,Antiviral,
Sequence
RFRPPIRRPPIRPPFYPPFRPPIRPPIFPPIRPPFRPPLGPFP
Function:Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms.

Top similar AMPs on LAMP
1. L02A000009 From 1 To 43 E-value: 0.0000000000004 Score: 65.5
RFRPPIRRPPIRPPFYPPFRPPIRPPIFPPIRPPFRPPLGPFP
2. L12A09969| From 1 To 35 E-value: 2.7 Score: 22.7
PPIQNPSMAPPTQNPYGQPMTPPTQNPYGQPMAPP

Reference
[1] Romeo D.,Przybylski M.,Schneider K.,Gennaro R.,Frank R.W.,
Title:Amino acid sequences of two proline-rich bactenecins. Antimicrobial peptides of bovine neutrophils.
Journal:J. Biol. Chem., 1990, 265, 18871-18874 [MEDLINE:91035404]
[2] Romeo D.,Schneider C.,Storici P.,del Sal G.,Zanetti M.,
Title:The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrophil antibiotics.
Journal:J. Biol. Chem., 1993, 268, 522-526 [MEDLINE:93107055]
[3] Edgerton M.,Marcus E.,Raj P.A.,
Title:Delineation of an active fragment and poly(L-proline) II conformation for candidacidal activity of bactenecin 5.
Journal:Biochemistry, 1996, 35, 4314-4325 [MEDLINE:96183292]
[4] Romeo D.,Lenarcic B.,Tossi A.,Storici P.,
Title:Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides.
Journal:Eur. J. Biochem., 1996, 238, 769-776 [MEDLINE:96300243]
[5] Womack J.E.,Elliott J.S.,Seabury C.M.,Gillenwaters E.N.,
Title:Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.
Journal:J. Hered., 2009, 100, 241-245 [PubMed:19136450]