Record in detail


General Info

  • lamp_id:L02A000165
  • Name:DMS3_PHYBI
  • FullName:Dermaseptin-B3
  • Source:Phyllomedusa bicolor
  • Mass:2909.5 Da
  • Sequence Length:29 aa
  • Isoelectric Point:10.8
  • Activity:Antibacterial,Antifungal,Antiviral,,Anticancer
  • Sequence
        ALWKNMLKGIGKLAGQAALGAVKTLVGAE
  • Function:Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A06201|    From 46 To 74 E-value: 0.00000000007 Score: 57.8
        ALWKNMLKGIGKLAGQAALGAVKTLVGAE
  • 2. L01A000454    From 1 To 29 E-value: 0.0000000003 Score: 55.5
        ALWKNMLKGIGKLAGQAALGAVKTLVGAE
  • 3. L02A000165    From 1 To 29 E-value: 0.0000000004 Score: 55.1
        ALWKNMLKGIGKLAGQAALGAVKTLVGAE
  • 4. L01A000151    From 1 To 28 E-value: 0.000000002 Score: 52.8
        ALWKNMLKGIGKLAGQAALGAVKTLVGA
  • 5. L01A000499    From 1 To 29 E-value: 0.000000006 Score: 51.2
        ALWKNMLKGIGKLAGKAALGAVKKLVGAE

Structure

  •   Domains
  •   1  Name:Brevinin    Interpro Link:IPR004275
  •   2  Name:Dermaseptin    Interpro Link:IPR022731
  •   3  Name:Dermaseptin_precursor    Interpro Link:IPR016322
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities
  •   1  Target:  E. coli  MIC:  4.36425 μg/ml  (1.5 μM)  
  •   2  Target:  S. aureus  MIC:  9.01945 μg/ml  (3.1 μM)  

Toxicity

  •   Toxicity

Reference

  •   Reference
  •   [1]  Le Caer J.-P.,Vouille V.,Mester J.,Amiche M.,Charpentier S.,
  •   Title:Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics.
  •   Journal:J. Biol. Chem., 1998, 273, 14690-14697  [MEDLINE:98278974]

Comments

  •   Comments

    •     No comments found on LAMP database



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