Record in detail

General Info

lamp_id:L02A000238
Name:WAG13_TROWA
FullName:Waglerin-3
Source:Tropidolaemus wagleri
Mass:2522 Da
Sequence Length:22 aa
Isoelectric Point:10.26
Activity:Antibacterial,Antifungal,Antiviral,
Sequence
GGKPDLRPCHPPCHYIPRPKPR
Function:Waglerin-1 selectively blocks the epsilon subunit of muscle nicotinic acetylcholine receptor (nAChR). Has also effects on rodent ionotropic GABA(A)/GABRA1 receptors, since it potentiates I(GABA) in some neurons and depresses I(GABA) in others. In mice, it elicits tachypnea, ocular proctosis, rapid collapse and spasms, whereas no toxic effects on respiration and blood pressure are observed in rats.

Cross-Linking

Cross-linking
1 Database:APD 238
2 Database:dbAMP dbAMP_02731
3 Database:SATPdb satpdb23604
4 Database:Uniprot P24335

Top similar AMPs

Top similar AMPs on LAMP
1. L02A000238 From 1 To 22 E-value: 0.0000002 Score: 46.2
GGKPDLRPCHPPCHYIPRPKPR

Structure

Domains
1 Name:Toxin_33 Interpro Link:IPR012637

Structures

Activity

Antibacterial Activities

Toxicity

Toxicity

Reference

Reference
[1] Smith L.A.,Bernheimer A.W.,Schmidt J.J.,Weinstein S.A.,
Title:Characterization and amino acid sequences of two lethal peptides isolated from venom of Wagler"s pit viper, Trimeresurus wagleri.
Journal:Toxicon, 1991, 29, 227-236 [MEDLINE:91263101]
[2] Smith L.A.,Weinstein S.A.,Schmidt J.J.,
Title:Molecular properties and structure-function relationships of lethal peptides from venom of Wagler"s pit viper, Trimeresurus wagleri.
Journal:Toxicon, 1992, 30, 1027-1036 [PubMed:1440639]
[3] Lee C.Y.,Smith L.A.,Lin W.W.,
Title:A study on the cause of death due to waglerin-I, a toxin from Trimeresurus wagleri.
Journal:Toxicon, 1995, 33, 111-114 [PubMed:7778124]
[4] Weinstein S.A.,Schmidt J.J.,
Title:Structure-function studies of waglerin I, a lethal peptide from the venom of Wagler"s pit viper, Trimeresurus wagleri.
Journal:Toxicon, 1995, 33, 1043-1049 [PubMed:8533138]
[5] McArdle J.J.,Schmidt J.J.,Annila A.,Mattila K.,Sellin L.C.,
Title:Conformational analysis of a toxic peptide from Trimeresurus wagleri which blocks the nicotinic acetylcholine receptor.
Journal:Biophys. J., 1996, 70, 3-13 [PubMed:8770182]
[6] Wu S.H.,Huang T.H.,Chen C.,Yu H.M.,Chuang L.C.,
Title:Determination of three-dimensional solution structure of waglerin I, a toxin from Trimeresurus wagleri, using 2D-NMR and molecular dynamics simulation.
Journal:Biochim. Biophys. Acta, 1996, 1292, 145-155 [PubMed:8547337]
[7] Wang K.-T.,Yu H.-M.,Chuang L.-C.,Chuang C.-C.,Hsiao Y.-M.,
Title:Protein engineering of venom toxins by synthetic approach and NMR dynamic simulation: status of basic amino acid residues in waglerin I.
Journal:Biochem. Biophys. Res. Commun., 1996, 227, 59-63 [PubMed:8858103]
[8] McArdle J.J.,Ye J.-H.,
Title:Waglerin-1 modulates gamma-aminobutyric acid activated current of murine hypothalamic neurons.
Journal:J. Pharmacol. Exp. Ther., 1997, 282, 74-80 [PubMed:9223541]
[9] Weinstein S.A.,Schwarz H.,Witzemann V.,Lentz T.L.,McArdle J.J.,
Title:Waglerin-1 selectively blocks the epsilon form of the muscle nicotinic acetylcholine receptor.
Journal:J. Pharmacol. Exp. Ther., 1999, 289, 543-550 [PubMed:10087048]
[10] Sine S.M.,McArdle J.J.,Kline E.F.,Rezai P.,Molles B.E.,
Title:Identification of residues at the alpha and epsilon subunit interfaces mediating species selectivity of Waglerin-1 for nicotinic acetylcholine receptors.
Journal:J. Biol. Chem., 2002, 277, 5433-5440 [PubMed:11724791]
[11] Taylor P.,Molles B.E.,
Title:Structure and function of the waglerins, peptide toxins from the venom of Wagler"s Pit Viper, Tropidolaemus wagleri.
Journal:J. Toxicol. Toxin Rev., 2002, 21, 273-292 [DOI:10.1081/TXR-120014406]

Comments

Comments