Record in detail

lamp_id:L02A000312
Name:DEFA1_MOUSE
FullName:Alpha-defensin 1
Source:Mus musculus
Mass:4136 Da
Sequence Length:35 aa
Isoelectric Point:9.57
Activity:Antibacterial,Antifungal,Antiviral,
Sequence
LRDLVCYCRARGCKGRERMNGTCRKGHLLYMLCCR
Function:Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S.typhimurium.

Top similar AMPs on LAMP
1. L03A000177 From 59 To 93 E-value: 2e-16 Score: 75.9
LRDLVCYCRARGCKGRERMNGTCRKGHLLYMLCCR
2. L03A000004 From 51 To 85 E-value: 5e-16 Score: 74.7
LRDLVCYCRSRGCKGRERMNGTCRKGHLLYMLCCR
3. L12A08317| From 59 To 93 E-value: 7e-16 Score: 74.3
LRDLVCYCRARGCKGRERMNGTCSKGHLLYMLCCR
4. L03A000156 From 59 To 93 E-value: 0.000000000000002 Score: 72.4
LRDLVCYCRSRGCKGRERMNGTCRKGHLLYTLCCR
5. L03A000178 From 59 To 93 E-value: 0.000000000000003 Score: 72
LRDLVCYCRSRGCKGRERMNGTCRKGHLMYTLCCR

Reference
[1] Naftilan J.,Frederick D.,James M.,Greco R.M.,Ouellette A.J.,
Title:Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium.
Journal:J. Cell Biol., 1989, 108, 1687-1695 [MEDLINE:89234158]
[2] Lauldi J.C.,Ouellette A.J.,
Title:A novel mouse gene family coding for cationic, cysteine-rich peptides. Regulation in small intestine and cells of myeloid origin.
Journal:J. Biol. Chem., 1990, 265, 9831-9837 [MEDLINE:90277674]
[3] Ouellette A.J.,Henschen A.H.,Miller S.I.,Selsted M.E.,
Title:Enteric defensins: antibiotic peptide components of intestinal host defense.
Journal:J. Cell Biol., 1992, 118, 929-936 [MEDLINE:92363933]
[4] Selsted M.E.,Henschen A.H.,Miller S.I.,Ouellette A.J.,
Title:Purification and primary structure of murine cryptdin-1, a Paneth cell defensin.
Journal:FEBS Lett., 1992, 304, 146-148 [MEDLINE:92316217]
[5] Ouellette A.J.,Selsted M.E.,Huttner K.M.,
Title:Structure and diversity of the murine cryptdin gene family.
Journal:Genomics, 1994, 19, 448-453 [MEDLINE:94245232]