Record in detail
General Info
- lamp_id:L03A000033
- Name:MEL_APIFL
- FullName:Melittin
- Source:Apis florea
- Mass:2819.4 Da
- Sequence Length:26 aa
- Isoelectric Point:12
- Activity:Antimicrobial
- Sequence
GIGAILKVLATGLPTLISWIKNKRKQ - Function:Main toxin of bee venom with strong hemolytic activity. Integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na(+)-K(+)-ATPase and the H(+)-K(+)-ATPase. Increases the permeability of cell membranes to ions, particularly Na(+) and indirectly Ca(2+), because of the Na(+)-Ca(2+)-exchange.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ7009
- 2 Database:dbAMP dbAMP_02883
- 3 Database:Uniprot P01504
- 4 Database:AMD MEL_APIFL
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L12A07868| From 44 To 69 E-value: 0.0000000007 Score: 54.3
GIGAILKVLATGLPTLISWIKNKRKQ - 2. L03A000033 From 1 To 26 E-value: 0.000000003 Score: 52
GIGAILKVLATGLPTLISWIKNKRKQ - 3. L12A02893| From 1 To 26 E-value: 0.0000002 Score: 46.6
GIGAVLKVLATGLPALISWIKRKRQQ - 4. L12A09068| From 41 To 66 E-value: 0.0000002 Score: 46.6
GIGAVLKVLTTGLPALISWIKRKRQQ - 5. L12A07874| From 44 To 69 E-value: 0.0000002 Score: 46.2
GIGAVLKVLTTGLPALISWIKRKRQQ
Structure
- Domains
- 1 Name:Melittin/Api_allergen Interpro Link:IPR002116
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Kreil G.
- Title:Structure of melittin isolated from two species of honey bees.
- Journal:FEBS Lett., 1973, 33, 241-244 [:]
Comments
- Comments
No comments found on LAMP database