Record in detail


General Info

  • lamp_id:L03A000034
  • Name:MEL_APIDO
  • FullName:Melittin
  • Source:Apis dorsata
  • Mass:2848.4 Da
  • Sequence Length:26 aa
  • Isoelectric Point:11.75
  • Activity:Antimicrobial
  • Sequence
        GIGAILKVLSTGLPALISWIKRKRQE
  • Function:Main toxin of bee venom with strong hemolytic activity. Integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na(+)-K(+)-ATPase and the H(+)-K(+)-ATPase. Increases the permeability of cell membranes to ions, particularly Na(+) and indirectly Ca(2+), because of the Na(+)-Ca(2+)-exchange.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000034    From 1 To 26 E-value: 0.000000003 Score: 52
        GIGAILKVLSTGLPALISWIKRKRQE
  • 2. L12A09068|    From 41 To 66 E-value: 0.000000005 Score: 51.6
        GIGAVLKVLTTGLPALISWIKRKRQQ
  • 3. L03A000139    From 44 To 69 E-value: 0.000000006 Score: 51.2
        GIGAVLKVLTTGLPALISWIKRKRQQ
  • 4. L12A07874|    From 44 To 69 E-value: 0.000000006 Score: 51.2
        GIGAVLKVLTTGLPALISWIKRKRQQ
  • 5. L13A027632    From 1 To 26 E-value: 0.000000008 Score: 50.8
        GIGAILKVLSTGLPALISWIKRKRQQ

Structure

  •   Domains
  •   1  Name:Melittin/Api_allergen    Interpro Link:IPR002116
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Kreil G.
  •   Title:The structure of Apis dorsata melittin: phylogenetic relationships between honeybees as deduced from sequence data.
  •   Journal:FEBS Lett., 1975, 54, 100-102  [MEDLINE:75168194]

Comments

  •   Comments

    •     No comments found on LAMP database



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