Record in detail
General Info
- lamp_id:L03A000057
- Name:MCDP_APIME
- FullName:Mast cell degranulating peptide
- Source:Apis mellifera
- Mass:2592.2 Da
- Sequence Length:22 aa
- Isoelectric Point:10.63
- Activity:Antimicrobial
- Sequence
IKCNCKRHVIKPHICRKICGKN - Function:Potent anti-inflammatory agent. At low concentrations, mediates the degranulation of mast cells thus evoking an inflammatory response. Also acts as a neurotoxin capable of blocking a class of voltage-gated potassium channels.
Cross-Linking
- Cross-linking
- 1 Database:Uniprot P01499
- 2 Database:AMD MCDP_APIME
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000057 From 1 To 22 E-value: 0.0000005 Score: 44.7
IKCNCKRHVIKPHICRKICGKN
Structure
- Domains
No domains found on LAMP database
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Haux P.
- Title:Amino acid sequence of MCD-peptide, a specific mast cell-degranulating peptide from bee venom.
- Journal:Hoppe-Seyler"s Z. Physiol. Chem., 1969, 350, 536-546 [MEDLINE:69219350]
- [2] Vernon C.A.,Shipolini R.A.,Hanson J.M.,Morley J.,Billingham M.E.J.,
- Title:An anti-inflammatory peptide from bee venom.
- Journal:Nature, 1973, 245, 163-164 [MEDLINE:74006387]
- [3] Vernon C.A.,Loudon A.G.,Hanson J.M.,Garman A.J.,Doonan S.,
- Title:Identification by mass spectrometry of N(epsilon)-formyl-lysine.
- Journal:J. Chem. Soc. Perkin Trans. I, 1978, 12, 1157-1160 [:]
- [4] Blume A.J.,Beer B.,Wang H.-C.,Russek S.,Ziai M.R.,
- Title:Mast cell degranulating peptide: a multi-functional neurotoxin.
- Journal:J. Pharm. Pharmacol., 1990, 42, 457-461 [MEDLINE:91108622]
- [5] Kreil G.,Gmachl M.,
- Title:The precursors of the bee venom constituents apamin and MCD peptide are encoded by two genes in tandem which share the same 3"-exon.
- Journal:J. Biol. Chem., 1995, 270, 12704-12708 [MEDLINE:95279409]
Comments
- Comments
No comments found on LAMP database