Record in detail


General Info

  • lamp_id:L03A000080
  • Name:DMS1_PACDA
  • FullName:Dermaseptin PD-1-5
  • Source:Pachymedusa dacnicolor
  • Mass:8463.8 Da
  • Sequence Length:77 aa
  • Isoelectric Point:5.15
  • Activity:Antimicrobial
  • Sequence
        MAFLKKSLFLVLFLGLVPLFLCENEKREGENEKEENDDQSEEKRSLGSFMKGVGKGLATVGKIVADQFGKLLEAGKG
  • Function:Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).

Cross-Linking

  •   Cross-linking
  •   1  Database:Uniprot  O93451
  •   2  Database:AMD  DMS1_PACDA

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000080    From 1 To 77 E-value: 3e-38 Score: 148
        MAFLKKSLFLVLFLGLVPLFLCENEKREGENEKEENDDQSEEKRSLGSFMKGVGKGLATVGKIVADQFGKLLEAGKG
  • 2. L03A000081    From 1 To 77 E-value: 0.00000000000001 Score: 70.5
        MAFLKKSLFLVLFLGLVPLSLCESEKREGENEEEQEDDQSEEKRSLGSFLKGVGTTLASVGKVVSDQFGKLLQAGQG
  • 3. L02A000908    From 1 To 33 E-value: 0.000000000001 Score: 63.5
        SLGSFMKGVGKGLATVGKIVADQFGKLLEAGKG
  • 4. L02A000907    From 1 To 33 E-value: 0.000000000003 Score: 62.4
        SLGSFMKGVGKGLATVGKIVADQFGKLLEAGQG
  • 5. L12A06177|    From 1 To 75 E-value: 0.00000000003 Score: 59.3
        MAFLKKSLFLVLFLGFVSVSICEEEKRQEDEDEHVEEGENQEEGSEEKRGLLSVLGSVAKHVLPHVVPVIAEHLG

Structure

  •   Domains
  •   1  Name:Brevinin    Interpro Link:IPR004275
  •   2  Name:Dermaseptin_precursor    Interpro Link:IPR016322
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

  •     No MICs found on LAMP database

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Wechselberger C.
  •   Title:Cloning of cDNAs encoding new peptides of the dermaseptin-family.
  •   Journal:Biochim. Biophys. Acta, 1998, 1388, 279-283  [MEDLINE:98449786]

Comments

  •   Comments

  •     No comments found on LAMP database



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