Record in detail
General Info
- lamp_id:L03A000100
- Name:HEPC_RAT
- FullName:Hepcidin
- Source:Rattus norvegicus
- Mass:9285.9 Da
- Sequence Length:84 aa
- Isoelectric Point:8.86
- Activity:Antimicrobial
- Sequence
MALSTRIQAACLLLLLLASLSSGAYLRQQTRQTTALQPWHGAESKTDDSALLMLKRRKRDTNFPICLFCCKCCKNSSCGLCCIT - Function:Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000100 From 1 To 84 E-value: 2.94273e-44 Score: 168
MALSTRIQAACLLLLLLASLSSGAYLRQQTRQTTALQPWHGAESKTDDSALLMLKRRKRDTNFPICLFCCKCCKNSSCGLCCIT - 2. L03A000101 From 1 To 83 E-value: 1e-23 Score: 100
MALSTRTQAACLLLLLLASLSSTTYLHQQMRQTTELQPLHGEESRA-DIAIPMQKRRKRDTNFPICIFCCKCCNNSQCGICCKT - 3. L01A003127 From 1 To 53 E-value: 7e-17 Score: 77.8
QMRQTTELQPLHGEESRAD-IAIPMQKRRKRDINFPICRFCCQCCNKPSCGICC - 4. L12A06392| From 1 To 87 E-value: 2e-16 Score: 76.3
MAQSTKIQAACLLLLLIAPQLLRAATEGTRVRQPEALQPQHRTADQTDRTDRTLLIPKRTKRDSHFPICIFCCYCCGNFKCGVCCKT - 5. L12A06333| From 1 To 84 E-value: 2e-16 Score: 75.9
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMLQ-RRRRRDTHFPICIFCCGCCHRSKCGMCCKT
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Turlin B.,Leroyer P.,Courselaud B.,Ilyin G.,Pigeon C.,
- Title:A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload.
- Journal:J. Biol. Chem., 2001, 276, 7811-7819 [MEDLINE:21269329]
Comments
- Comments
No comments found on LAMP database