Record in detail


General Info

  • lamp_id:L03A000100
  • Name:HEPC_RAT
  • FullName:Hepcidin
  • Source:Rattus norvegicus
  • Mass:9285.9 Da
  • Sequence Length:84 aa
  • Isoelectric Point:8.86
  • Activity:Antimicrobial
  • Sequence
        MALSTRIQAACLLLLLLASLSSGAYLRQQTRQTTALQPWHGAESKTDDSALLMLKRRKRDTNFPICLFCCKCCKNSSCGLCCIT
  • Function:Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).

Cross-Linking

  •   Cross-linking
  •   1  Database:Uniprot  Q99MH3
  •   2  Database:AMD  HEPC_RAT

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000100    From 1 To 84 E-value: 2.94273e-44 Score: 168
        MALSTRIQAACLLLLLLASLSSGAYLRQQTRQTTALQPWHGAESKTDDSALLMLKRRKRDTNFPICLFCCKCCKNSSCGLCCIT
  • 2. L03A000101    From 1 To 83 E-value: 1e-23 Score: 100
        MALSTRTQAACLLLLLLASLSSTTYLHQQMRQTTELQPLHGEESRA-DIAIPMQKRRKRDTNFPICIFCCKCCNNSQCGICCKT
  • 3. L01A003127    From 1 To 53 E-value: 7e-17 Score: 77.8
        QMRQTTELQPLHGEESRAD-IAIPMQKRRKRDINFPICRFCCQCCNKPSCGICC
  • 4. L12A06392|    From 1 To 87 E-value: 2e-16 Score: 76.3
        MAQSTKIQAACLLLLLIAPQLLRAATEGTRVRQPEALQPQHRTADQTDRTDRTLLIPKRTKRDSHFPICIFCCYCCGNFKCGVCCKT
  • 5. L12A06333|    From 1 To 84 E-value: 2e-16 Score: 75.9
        MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMLQ-RRRRRDTHFPICIFCCGCCHRSKCGMCCKT

Structure

  •   Domains
  •   1  Name:Hepcidin    Interpro Link:IPR010500
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

  •     No MICs found on LAMP database

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Turlin B.,Leroyer P.,Courselaud B.,Ilyin G.,Pigeon C.,
  •   Title:A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload.
  •   Journal:J. Biol. Chem., 2001, 276, 7811-7819  [MEDLINE:21269329]

Comments

  •   Comments

  •     No comments found on LAMP database



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