Record in detail


General Info

  • lamp_id:L03A000103
  • Name:DMS2_PACDA
  • FullName:Dermaseptin PD-2-2
  • Source:Pachymedusa dacnicolor
  • Mass:8507.7 Da
  • Sequence Length:75 aa
  • Isoelectric Point:4.52
  • Activity:Antimicrobial
  • Sequence
        MALVKKSLFLVLFLGLVSLSICEEKRENEDEEEQEDDEQSEEKRALWKTLLKKVGKVAGKAVLNAVTNMANQNEQ
  • Function:Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).

Cross-Linking

  •   Cross-linking
  •   1  Database:Uniprot  O93452
  •   2  Database:AMD  DMS2_PACDA

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000103    From 1 To 75 E-value: 1e-37 Score: 146
        MALVKKSLFLVLFLGLVSLSICEEKRENEDEEEQEDDEQSEEKRALWKTLLKKVGKVAGKAVLNAVTNMANQNEQ
  • 2. L12A06608|    From 1 To 76 E-value: 7e-17 Score: 77.8
        MDILKKSLFIVLFLGLVSLSICEEEKRENEDEEEQEDDEQSEEKRALWKSLLKNVGVAAGKAALNAVTDMVNQGEQ
  • 3. L12A06610|    From 1 To 76 E-value: 8e-17 Score: 77.4
        MDILKKSLFLVLFLGLISLSFCEEEKRENEDEEEQEDDEQSEEKRGLWKSLLKNVGKAAGKAALNAVTDMVNQGEQ
  • 4. L12A06609|    From 1 To 76 E-value: 2e-16 Score: 76.3
        MDILKKSLFIVLFLGLVSLSICEEEKRENEDEEEQEDDEQSEEKRGLWKSLLKNVGVAAGKAALNAVTDMVNQGEQ
  • 5. L12A06183|    From 1 To 76 E-value: 0.000000000000001 Score: 73.9
        MAFLKKSLFLVLFLGLVSLSICEEEKRENKDEIEQEDDEQSEEKRALWKDILKNVGKAAGKAVLNTVTDMVNQGEQ

Structure

  •   Domains
  •   1  Name:Brevinin    Interpro Link:IPR004275
  •   2  Name:Dermaseptin    Interpro Link:IPR022731
  •   3  Name:Dermaseptin_precursor    Interpro Link:IPR016322
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Wechselberger C.
  •   Title:Cloning of cDNAs encoding new peptides of the dermaseptin-family.
  •   Journal:Biochim. Biophys. Acta, 1998, 1388, 279-283  [MEDLINE:98449786]

Comments

  •   Comments

    •     No comments found on LAMP database



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