Record in detail
General Info
- lamp_id:L03A000117
- Name:RLXN_LITCT
- FullName:Ranalexin
- Source:Lithobates catesbeiana
- Mass:7614.9 Da
- Sequence Length:66 aa
- Isoelectric Point:5.11
- Activity:Antimicrobial
- Sequence
MFTLKKSLLLLFFLGTINLSLCEEERNAEEERRDNPDERDVEVEKRFLGGLIKIVPAMICAVTKKC - Function:Potent microbicidal activity, active against S.aureus and E.coli. It acts as well as a membrane-disruptive agent at higher concentrations.
Cross-Linking
- Cross-linking
- 1 Database:dbAMP dbAMP_07065
- 2 Database:Uniprot P39084
- 3 Database:AMD RLXN_RANCA
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000117 From 1 To 66 E-value: 3e-33 Score: 132
MFTLKKSLLLLFFLGTINLSLCEEERNAEEERRDNPDERDVEVEKRFLGGLIKIVPAMICAVTKKC - 2. L12A07345| From 1 To 67 E-value: 3e-24 Score: 102
MFTMKKSMLLLFFLGTINLSLCEQERDAEEERRDDEDKRDVEVEKRFALGAVTKLLPSLLCMISRKC - 3. L12A07221| From 1 To 67 E-value: 1e-22 Score: 97.1
MFTMKKPMLLLFFLGTINLSLCEQERDAEEERRDDEDKRDVEVEKRFALGAVTKRLPSLFCLITRRC - 4. L12A07365| From 1 To 70 E-value: 4e-22 Score: 95.1
MFTTKKPMLLLFFLGTINFSLCEQERDAEEERRDDQDKRDVEVEKRFFLPLLGAAAQVLPSLICKIFKKC - 5. L12A07168| From 1 To 71 E-value: 9e-22 Score: 94
MFTLKKSMLLLFFLGTINLSLCEQERNADEEERRDNPDEMDVVVEKRFLPLLAGLAANFLPQIICKIARKC
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Zasloff M.,Maloy W.L.,Durell S.,Clark D.P.,
- Title:Ranalexin. A novel antimicrobial peptide from bullfrog (Rana catesbeiana) skin, structurally related to the bacterial antibiotic, polymyxin.
- Journal:J. Biol. Chem., 1994, 269, 10849-10855 [MEDLINE:94193792]
- [2] Grassy G.,Chiche L.,Roch P.,Chavanieu A.,Vignal E.,
- Title:Solution structure of the antimicrobial peptide ranalexin and a study of its interaction with perdeuterated dodecylphosphocholine micelles.
- Journal:Eur. J. Biochem., 1998, 253, 221-228 [MEDLINE:98237592]
Comments
- Comments
No comments found on LAMP database