Record in detail
General Info
- lamp_id:L03A000125
- Name:PFPA_ENTHI
- FullName:Pore-forming peptide ameobapore A
- Source:Entamoeba histolytica
- Mass:10504.3 Da
- Sequence Length:98 aa
- Isoelectric Point:7.21
- Activity:Antimicrobial
- Sequence
MKAIVFVLIFAVAFAVTATHQGEILCNLCTGLINTLENLLTTKGADKVKDYISSLCNKASGFIATLCTKVLDFGIDKLIQLIEDKVDANAICAKIHAC - Function:Forms pores in the cytoplasmic membrane of host cells. Has antibacterial activity against M.luteus, no activity against E.coli. Implicated in the cytolytic activity of the parasite.
Cross-Linking
- Cross-linking
- 1 Database:dbAMP dbAMP_07600
- 2 Database:Uniprot P34095
- 3 Database:AMD PFP_ENTHI
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000125 From 1 To 98 E-value: 0 Score: 192
MKAIVFVLIFAVAFAVTATHQGEILCNLCTGLINTLENLLTTKGADKVKDYISSLCNKASGFIATLCTKVLDFGIDKLIQLIEDKVDANAICAKIHAC - 2. L03A000126 From 1 To 97 E-value: 0 Score: 176
MKAIVFVLIFAVAFAVT-LRQGPIVCNLCTGLINTLENLLTTKGADKVKDYIDSLCNKASGFIATLCTKVLDFGVDKLIQLIEDKVDANAICAKIHAC - 3. L01A000511 From 1 To 77 E-value: 1e-39 Score: 152
GEILCNLCTGLINTLENLLTTKGADKVKDYISSLCNKASGFIATLCTKVLDFGIDKLIQLIEDKVDANAICAKIHAC - 4. L03A000240 From 1 To 96 E-value: 1e-30 Score: 123
MRAIVFVLIFAIAFA--ATREGSILCNLCKDTVNLIENLLTVDGAQAVRQYIDNLCAKADGFLGTLCNKILSFGVDELVKLIENHVDPVVICEKIHAC - 5. L03A000239 From 1 To 96 E-value: 4e-30 Score: 121
MRAIIFVLIFAIAFA--ATREGAILCNLCKDTVKLVENLLTVDGAQAVRQYIDNLCGKASGFLGTLCEKILSFGVDELVKLIENHVDPVVVCEKIHAC
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Mueller-Eberhard H.J.,Horstmann R.D.,Schoenberger O.L.,Ebel S.,Leippe M.,
- Title:Pore-forming peptide of pathogenic Entamoeba histolytica.
- Journal:Proc. Natl. Acad. Sci. U.S.A., 1991, 88, 7659-7663 [MEDLINE:91352048]
- [2] Pattus F.,van der Goot G.,Nickel R.,Tannich E.,Leippe M.,
- Title:Primary and secondary structure of the pore-forming peptide of pathogenic Entamoeba histolytica.
- Journal:EMBO J., 1992, 11, 3501-3506 [MEDLINE:93010939]
- [3] Tannich E.,Lioutas C.,Leippe M.,Bruchhaus I.,
- Title:Unusual gene organization in the protozoan parasite Entamoeba histolytica.
- Journal:DNA Cell Biol., 1993, 12, 925-933 [MEDLINE:94099892]
- [4] Mueller-Eberhard H.J.,Tannich E.,Nickel R.,Andrae J.,Leippe M.,
- Title:Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: isolation, primary structure, and pore formation in bacterial cytoplasmic membranes.
- Journal:Mol. Microbiol., 1994, 14, 895-904 [MEDLINE:95231296]
Comments
- Comments
No comments found on LAMP database