Record in detail

lamp_id:L03A000145
Name:CHY1_PAGMA
FullName:Chrysophsin-1
Source:Pagrus major
Mass:7721.1 Da
Sequence Length:68 aa
Isoelectric Point:8.5
Activity:Antimicrobial
Sequence
MKFTATFLMLFIFVLMVEPGECGWKKWFNRAKKVGKTVGGLAVDHYLGKQPELDKRAVDEDPSAIVFD
Function:Has antibacterial activity against Gram-positive bacteria B.subtilis ATCC 6633, L.garvieae ATCC 49156 and S.iniae F-8502, and Gram-negative bacteria E.coli WT-2, V.anguillarum ATCC 19264, V.penaeicida KHA, V.harveyi ATCC 14126, V.vulnificus ATCC 33148, A.salmonicida NCMB 1102 and P.putida ATCC 12633. Has hemolytic activity against human red blood cells. Seems to disrupt the membranes by adopting an alpha helical conformation. May play a significant role in innate host defense.

Top similar AMPs on LAMP
1. L03A000145 From 1 To 68 E-value: 4e-36 Score: 141
MKFTATFLMLFIFVLMVEPGECGWKKWFNRAKKVGKTVGGLAVDHYLGKQPELDKRAVDEDPSAIVFD
2. L03A000146 From 1 To 68 E-value: 7e-32 Score: 127
MKFTATFLMLFIFVLMVEPGECGWKSVFRKAKKVGKTVGGLALDHYLGEQQELDKRAVDEDPSAIVFD
3. L03A000141 From 1 To 66 E-value: 1e-24 Score: 103
MKFTANFLMLFIFVLMFEPGECGWRTLLKKAEV--KTVGKLALKHYLGKQPELDKRAIDDDPSIIVFD
4. L12A07889| From 1 To 68 E-value: 2e-24 Score: 102
MKFTATFLMMFIFVLMVEPGECGWGSIFKHGRHAAKHIGHAAVNHYLGEQQDLDKRAVDEDPNVIVFE
5. L12A07888| From 1 To 68 E-value: 8e-24 Score: 100
MKFTATFLMMAIFVLMVEPGECGWGSFFKKAAHVGKHVGKAALTHYLGDKQELNKRAVDEDPNVIVFE

Reference
[1] Uematsu K.,Morita Y.,Emoto Y.,Tanimoto N.,Iijima N.,
Title:Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major.
Journal:Eur. J. Biochem., 2003, 270, 675-686 [MEDLINE:22469439]