Record in detail
General Info
- lamp_id:L03A000197
- Name:DMYC_DROME
- FullName:Drosomycin
- Source:Drosophila melanogaster
- Mass:7752 Da
- Sequence Length:70 aa
- Isoelectric Point:6.98
- Activity:Antimicrobial
- Sequence
MMQIKYLFALFAVLMLVVLGANEADADCLSGRYKGPCAVWDNETCRRVCKEEGRSSGHCSPSLKCWCEGC - Function:Possesses antifungal activity and is active against a relatively broad spectrum of filamentous fungi. It inhibits spore germination at high concentrations and at low concentrations delays growth of hyphae which subsequently exhibit abnormal morphology. Spz C-106 in the hemolymph controls expression of the antifungal peptide by acting as a ligand of Tl and inducing an intracellular signaling pathway.
Cross-Linking
- Cross-linking
- 1 Database:dbAMP dbAMP_08497
- 2 Database:Uniprot P41964
- 3 Database:AMD DMYC_DROME
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000197 From 1 To 70 E-value: 1e-37 Score: 146
MMQIKYLFALFAVLMLVVLGANEADADCLSGRYKGPCAVWDNETCRRVCKEEGRSSGHCSPSLKCWCEGC - 2. L01A000075 From 1 To 44 E-value: 5e-22 Score: 94.7
DCLSGRYKGPCAVWDNETCRRVCKEEGRSSGHCSPSLKCWCEGC - 3. L13A022558 From 1 To 43 E-value: 3e-21 Score: 92.4
CLSGRYKGPCAVWDNETCRRVCKEEGRSSGHCSPSLKCWCEGC - 4. L01A002966 From 1 To 71 E-value: 1e-20 Score: 90.5
MIQIKFLCLFLAIMTIVVLDSNVAEARDCLSGTFKGPCWAWSGEKCRRLCIEEGRVSGHCSGGSKCWCEGC - 5. L02A001551 From 1 To 44 E-value: 1e-19 Score: 87
DCLSGKYKGPCAVWDNEMCRRICKEEGHISGHCSPSLKCWCEGC
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Broekaert W.F.,Lagueux M.,Michaut L.,Bulet P.,Fehlbaum P.,
- Title:Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides.
- Journal:J. Biol. Chem., 1994, 269, 33159-33163 [MEDLINE:95105209]
- [2] Hoffmann J.A.,Reichhart J.-M.,Michaut L.,Nicolas E.,Lemaitre B.,
- Title:The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults.
- Journal:Cell, 1996, 86, 973-983 [MEDLINE:96404450]
- [3] Ptak M.,Hoffmann J.A.,Hetru C.,Sodano P.,Landon C.,
- Title:Solution structure of drosomycin, the first inducible antifungal protein from insects.
- Journal:Protein Sci., 1997, 6, 1878-1884 [MEDLINE:97445602]
- [4] Hoffmann J.A.,van Dorsselaer A.,Lagueux M.,Moniatte M.,Uttenweiler-Joseph S.,
- Title:Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study.
- Journal:Proc. Natl. Acad. Sci. U.S.A., 1998, 95, 11342-11347 [MEDLINE:98409659]
- [5] Gocayne J.D.,Evans C.A.,Holt R.A.,Celniker S.E.,Adams M.D.,
- Title:The genome sequence of Drosophila melanogaster.
- Journal:Science, 2000, 287, 2185-2195 [MEDLINE:20196006]
- [6] Champe M.,Yu C.,Brokstein P.,Carlson J.W.,Stapleton M.,
- Title:A Drosophila full-length cDNA resource.
- Journal:Genome Biol., 2002, 3, 0-0 [MEDLINE:22426066]
- [7] Campbell K.S.,Matthews B.B.,Mungall C.J.,Crosby M.A.,Misra S.,
- Title:Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
- Journal:Genome Biol., 2002, 3, 0-0 [MEDLINE:22426069]
- [8] Gascan H.,Lelievre E.,Hoffmann J.A.,Tauszig-Delamasure S.,Weber A.N.,
- Title:Binding of the Drosophila cytokine Spatzle to Toll is direct and establishes signaling.
- Journal:Nat. Immunol., 2003, 4, 794-800 [MEDLINE:22770739]
- [9] Kim K.W.,Jiggins F.M.,
- Title:The evolution of antifungal peptides in Drosophila.
- Journal:Genetics, 2005, 171, 1847-1859 [PubMed:16157672]
Comments
- Comments
No comments found on LAMP database