Record in detail
General Info
- lamp_id:L03A000237
- Name:MTK_DROME
- FullName:Metchnikowin
- Source:Drosophila melanogaster
- Mass:5653.5 Da
- Sequence Length:52 aa
- Isoelectric Point:9.35
- Activity:Antimicrobial
- Sequence
MQLNLGAIFLALLGVMATATSVLAEPHRHQGPIFDTRPSPFNPNQPRPGPIY - Function:Potent antifungal and antibacterial activity against Gram-positive bacteria.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ6726
- 2 Database:dbAMP dbAMP_08949
- 3 Database:Uniprot Q24395
- 4 Database:AMD MTK_DROME
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000237 From 1 To 52 E-value: 8e-26 Score: 107
MQLNLGAIFLALLGVMATATSVLAEPHRHQGPIFDTRPSPFNPNQPRPGPIY - 2. L12A08948| From 1 To 52 E-value: 2e-25 Score: 105
MQLNLGAIFLALLGLMATATSVLAEPHRHQGPIFDTRPSPFNPNQPRPGPIY - 3. L01A000293 From 1 To 26 E-value: 0.00000000005 Score: 58.2
HRHQGPIFDTRPSPFNPNQPRPGPIY - 4. L11A013147 From 1 To 26 E-value: 0.0000000003 Score: 55.5
HRRQGPIFDTRPSPFNPNQPRPGPIY - 5. L01A000707 From 1 To 25 E-value: 0.000000002 Score: 53.1
RRQGPIFDTRPSPFNPNQPRPGPIY
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Hetru C.,Reichhart J.-M.,Bulet P.,Ohresser S.,Levashina E.A.,
- Title:Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties.
- Journal:Eur. J. Biochem., 1995, 233, 694-700 [MEDLINE:96067716]
- [2] Hoffmann J.A.,van Dorsselaer A.,Lagueux M.,Moniatte M.,Uttenweiler-Joseph S.,
- Title:Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study.
- Journal:Proc. Natl. Acad. Sci. U.S.A., 1998, 95, 11342-11347 [MEDLINE:98409659]
- [3] Imler J.-L.,Lemaitre B.,Ohresser S.,Levashina E.A.,
- Title:Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin.
- Journal:J. Mol. Biol., 1998, 278, 515-527 [MEDLINE:98263241]
- [4] Gocayne J.D.,Evans C.A.,Holt R.A.,Celniker S.E.,Adams M.D.,
- Title:The genome sequence of Drosophila melanogaster.
- Journal:Science, 2000, 287, 2185-2195 [MEDLINE:20196006]
- [5] Champe M.,Yu C.,Brokstein P.,Carlson J.W.,Stapleton M.,
- Title:A Drosophila full-length cDNA resource.
- Journal:Genome Biol., 2002, 3, 0-0 [MEDLINE:22426066]
- [6] Campbell K.S.,Matthews B.B.,Mungall C.J.,Crosby M.A.,Misra S.,
- Title:Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
- Journal:Genome Biol., 2002, 3, 0-0 [MEDLINE:22426069]
- [7] Clark A.G.,Lazzaro B.P.,
- Title:Molecular population genetics of inducible antibacterial peptide genes in Drosophila melanogaster.
- Journal:Mol. Biol. Evol., 2003, 20, 914-923 [MEDLINE:22625906]
Comments
- Comments
No comments found on LAMP database