Record in detail
General Info
- lamp_id:L03A000239
- Name:PFPB_ENTHI
- FullName:Pore-forming peptide ameobapore B
- Source:Entamoeba histolytica
- Mass:10437.3 Da
- Sequence Length:96 aa
- Isoelectric Point:5.65
- Activity:Antimicrobial
- Sequence
MRAIIFVLIFAIAFAATREGAILCNLCKDTVKLVENLLTVDGAQAVRQYIDNLCGKASGFLGTLCEKILSFGVDELVKLIENHVDPVVVCEKIHAC - Function:Forms pores in the cytoplasmic membrane of host cells. Has antibacterial activity against M.luteus, no activity against E.coli. Implicated in the cytolytic activity of the parasite.
Cross-Linking
- Cross-linking
- 1 Database:dbAMP dbAMP_08996
- 2 Database:Uniprot Q24824
- 3 Database:AMD PFPB_ENTHI
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000239 From 1 To 96 E-value: 0 Score: 192
MRAIIFVLIFAIAFAATREGAILCNLCKDTVKLVENLLTVDGAQAVRQYIDNLCGKASGFLGTLCEKILSFGVDELVKLIENHVDPVVVCEKIHAC - 2. L03A000240 From 1 To 96 E-value: 0 Score: 182
MRAIVFVLIFAIAFAATREGSILCNLCKDTVNLIENLLTVDGAQAVRQYIDNLCAKADGFLGTLCNKILSFGVDELVKLIENHVDPVVICEKIHAC - 3. L01A002957 From 1 To 77 E-value: 2e-40 Score: 156
GAILCNLCKDTVKLVENLLTVDGAQAVRQYIDNLCGKASGFLGTLCEKILSFGVDELVKLIENHVDPVVVCEKIHAC - 4. L03A000126 From 1 To 97 E-value: 6e-31 Score: 124
MKAIVFVLIFAVAFAVTLRQGPIVCNLCTGLINTLENLLTTKGADKVKDYIDSLCNKASGFIATLCTKVLDFGVDKLIQLIEDKVDANAICAKIHAC - 5. L03A000125 From 1 To 98 E-value: 4e-30 Score: 121
MKAIVFVLIFAVAFAVTATHQGEILCNLCTGLINTLENLLTTKGADKVKDYISSLCNKASGFIATLCTKVLDFGIDKLIQLIEDKVDANAICAKIHAC
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Mueller-Eberhard H.J.,Tannich E.,Nickel R.,Andrae J.,Leippe M.,
- Title:Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: isolation, primary structure, and pore formation in bacterial cytoplasmic membranes.
- Journal:Mol. Microbiol., 1994, 14, 895-904 [MEDLINE:95231296]
Comments
- Comments
No comments found on LAMP database